927732
C5 Lenalidomide-difluoroPEG1-C4-piperazine Hydrochloride
≥95%
Manufacturer: Sigma Aldrich
Synonym(S): 2-(2,2-Difluoro-3-(4-(piperazin-1-yl)butoxy)propoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)acetamide Hydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 927732-50-MG | In Stock | ₹ 60,850.00 |
927732 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 60,850.00
GST (18%): ₹ 10,953.00
Total Price: ₹ 71,803.00
ligand
C5 Lenalidomide
Quality Level
100
Assay
≥95%
form
powder
storage temp.
2-8°C
SMILES string
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCC(F)(F)COCCCCN4CCNCC4)=O)=CC=C31.Cl
Related Products
Description
- Application: Protein degrader building block C5 Lenalidomide-difluoroPEG1-C4-piperazine Hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a fluorinated linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Targeted Protein Degradation
SAFETY INFORMATION
Pictograms
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2 - STOT RE 2
Target Organs
Blood
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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ligand: C5 Lenalidomide
Quality Level: 100
Assay: ≥95%
form: powder
storage temp.: 2-8°C
SMILES string: O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCC(F)(F)COCCCCN4CCNCC4)=O)=CC=C31.Cl
ligand:
C5 Lenalidomide
Quality Level:
100
Assay:
≥95%
form:
powder
storage temp.:
2-8°C
SMILES string:
O=C1N(C2CCC(NC2=O)=O)CC3=CC(NC(COCC(F)(F)COCCCCN4CCNCC4)=O)=CC=C31.Cl
ligand: __
Quality Level: 100
Assay: __
form: solid
storage temp.: __
SMILES string: Cl[Pd]Cl.c1ccc(cc1)P(c2ccccc2)c3ccccc3.c4ccc(cc4)P(c5ccccc5)c6ccccc6
ligand:
__
Quality Level:
100
Assay:
__
form:
solid
storage temp.:
__
SMILES string:
Cl[Pd]Cl.c1ccc(cc1)P(c2ccccc2)c3ccccc3.c4ccc(cc4)P(c5ccccc5)c6ccccc6
ligand: __
Quality Level: 100
Assay: __
form: solid
storage temp.: __
SMILES string: Cl[Pd@@]1(C2=C(C3=C(N1)C=CC=C3)C=CC=C2)P(C4CCCCC4)(C5=CC=CC=C5C6=C(C(C)C)C=C(C(C)C)C=C6C(C)C)C7CCCCC7
ligand:
__
Quality Level:
100
Assay:
__
form:
solid
storage temp.:
__
SMILES string:
Cl[Pd@@]1(C2=C(C3=C(N1)C=CC=C3)C=CC=C2)P(C4CCCCC4)(C5=CC=CC=C5C6=C(C(C)C)C=C(C(C)C)C=C6C(C)C)C7CCCCC7
ligand: __
Quality Level: 100
Assay: __
form: solid
storage temp.: __
SMILES string: __
ligand:
__
Quality Level:
100
Assay:
__
form:
solid
storage temp.:
__
SMILES string:
__