Description

• Application: 3-[1,3-Dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione is a functionalized cereblon (CRBN) ligand used in the development of lenalidomide-based protein degrader building blocks. Can be activated by many nucleophiles or form ether linkages through its terminal hydroxyl group. A basic building block for development of a protein degrader library.Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationProtein Degrader Building Blocks
• Other Notes: Targeted Protein Degradation by Small MoleculesDestruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERGSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs
• Legal Information: PROTAC®