930822
3-[1,3-Dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
≥95.0%
Manufacturer: Sigma Aldrich
CAS Number: 2138441-30-0
Synonym(S): 2,6-Piperidinedione, 3-[1,3-dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 MG | 930822-50-MG | In Stock | ₹ 15,940.00 |
930822 - 50 MG
In Stock
Quantity
1
Base Price: ₹ 15,940.00
GST (18%): ₹ 2,869.20
Total Price: ₹ 18,809.20
Quality Level
100
Assay
≥95.0%
form
powder
functional group
hydroxyl
storage temp.
2-8°C
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | 2138441-30-0 | Phthalimidinoglutarimide-propargyl-C2-OH | A2B Chem | ₹ 26,951.40 - ₹ 2,19,461.40 |
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Description
- Application: 3-[1,3-Dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione is a functionalized cereblon (CRBN) ligand used in the development of lenalidomide-based protein degrader building blocks. Can be activated by many nucleophiles or form ether linkages through its terminal hydroxyl group. A basic building block for development of a protein degrader library.Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationProtein Degrader Building Blocks
- Other Notes: Targeted Protein Degradation by Small MoleculesDestruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERGSmall-Molecule PROTACS: New Approaches to Protein DegradationTargeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs
- Legal Information: PROTAC®
SAFETY INFORMATION
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Quality Level: 100
Assay: ≥95.0%
form: powder
functional group: hydroxyl
storage temp.: 2-8°C
Quality Level:
100
Assay:
≥95.0%
form:
powder
functional group:
hydroxyl
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2-8°C
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functional group: __
storage temp.: __
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Quality Level:
100
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__
form:
powder
functional group:
__
storage temp.:
−20°C
Quality Level: 100
Assay: ≥95%
form: powder
functional group: __
storage temp.: −20°C
Quality Level:
100
Assay:
≥95%
form:
powder
functional group:
__
storage temp.:
−20°C