5545839

Tocris Bioscience™ JIB 04

Pan Jumonji inhibitor; active in vivo

Manufacturer: Fischer Scientific

The price for this product is unavailable. Please request a quote

Purity

>99%

Product Type

JIB 04

Molecular Weight (g/mol)

308.76

Inhibitors

JIB 04

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Description

  • Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively)
  • Exhibits negligible activity at PHD2 and TET1
  • Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo
  • Prolongs survival in a mouse model of breast cancer.

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