68-155-0
Tocris™ Selumetinib
Manufacturer: Tocris™
CAS Number: 606143-52-6
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Chemical Name or Material
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
Synonym
calcium sensor protein, DBS, DBSlow-density lipoprotein receptor-related protein 2, EC 1.1.2.3, EC 3.4.21.9, Glycoprotein 330, GP330, Heymann nephritis antigen homolog, low density lipoprotein receptor-related protein 2, LRP2, LRP-2, megalin
Molecular Formula
C17H15BrClFN4O3
Product Type
Inhibitor
CAS
606143-52-6
Quantity
50 mg
Formula Weight
457.68
Purity
98%
Other Options
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Description
- Selumetinib is a potent and selective MEK inhibitor (IC50 = 14 nM for MEK1, Kd = 530 nM for MEK2)
- Inhibits ERK1/2 phosphorylation (IC50 = 10 nM)
- Exhibits no activity at p38α, MKK6, EGFR, ErbB2 and ERK2
- Suppresses several cell lines containing B-Raf and Ras mutations, but displays no effect on a normal fibroblast cell lines
- Inhibits tumor growth in colorectal tumor xenograft model
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: 5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
Synonym: calcium sensor protein, DBS, DBSlow-density lipoprotein receptor-related protein 2, EC 1.1.2.3, EC 3.4.21.9, Glycoprotein 330, GP330, Heymann nephritis antigen homolog, low density lipoprotein receptor-related protein 2, LRP2, LRP-2, megalin
Molecular Formula: C17H15BrClFN4O3
Product Type: Inhibitor
CAS: 606143-52-6
Quantity: 50 mg
Formula Weight: 457.68
Purity: 98%
Chemical Name or Material:
5-[(4-Bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide
Synonym:
calcium sensor protein, DBS, DBSlow-density lipoprotein receptor-related protein 2, EC 1.1.2.3, EC 3.4.21.9, Glycoprotein 330, GP330, Heymann nephritis antigen homolog, low density lipoprotein receptor-related protein 2, LRP2, LRP-2, megalin
Molecular Formula:
C17H15BrClFN4O3
Product Type:
Inhibitor
CAS:
606143-52-6
Quantity:
50 mg
Formula Weight:
457.68
Purity:
98%
Chemical Name or Material: (3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
Synonym: __
Molecular Formula: C16H15F6N5O.H3O4P
Product Type: __
CAS: 654671-78-0
Quantity: 10 mg
Formula Weight: 505.31
Purity: 98%
Chemical Name or Material:
(3R)-3-Amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone phosphate
Synonym:
__
Molecular Formula:
C16H15F6N5O.H3O4P
Product Type:
__
CAS:
654671-78-0
Quantity:
10 mg
Formula Weight:
505.31
Purity:
98%
Chemical Name or Material: __
Synonym: __
Molecular Formula: C16H22N2O2S·HCl
Product Type: __
CAS: 61714-25-8
Quantity: 1 mg
Formula Weight: 342.9g/mol
Purity: __
Chemical Name or Material:
__
Synonym:
__
Molecular Formula:
C16H22N2O2S·HCl
Product Type:
__
CAS:
61714-25-8
Quantity:
1 mg
Formula Weight:
342.9g/mol
Purity:
__
Chemical Name or Material: __
Synonym: __
Molecular Formula: C16H21ClN2O2S·HCl
Product Type: __
CAS: 61714-27-0
Quantity: 10 mg
Formula Weight: 377.4g/mol
Purity: __
Chemical Name or Material:
__
Synonym:
__
Molecular Formula:
C16H21ClN2O2S·HCl
Product Type:
__
CAS:
61714-27-0
Quantity:
10 mg
Formula Weight:
377.4g/mol
Purity:
__