69-145
Tocris™ dTAGV-1
Manufacturer: Tocris™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 69-145-Each-of-1 | In Stock | ₹ 57,983.50 |
69-145 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 57,983.50
GST (18%): ₹ 10,437.03
Total Price: ₹ 68,420.53
Chemical Name or Material
(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-((-1-((2 S,4 R)-4-hydroxy-2-((-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl -1-(-2-(3,4,5-trimethoxyph)
Target
TAG Degradation Platforms
Purity
0.98
Quantity
5 mg
Molecular Formula
C68H90N6O14S CF3CO2H
Related Products
Description
- dTAGV-1 is a degrader targeting mutant FKBP12F36V fusion proteins
- Comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a von Hippel-Lindau (VHL)-binding ligand
- Induces potent and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo
- Selectively degrades FKBP12F36V-EWS/FLI fusion proteins and inhibits cell proliferation in FKBP12F36V-EWS/FLI-expressing Ewing sarcoma cells
- Hydrochloride salt (Cat.No
- 7374) available; suitable for in vivo use
- Negative control dTAGV-1-NEG (Cat
- No
- 6915) also available
- FKBP12F36V can be expressed as a fusion with a target protein of interest using genome engineering techniques, via transgene expression or CRISPR-mediated locus-specific knock-in
- Custom knock-in cell lines for the dTAG and aTAG platforms are available from our sister brand R&D Systems
- Email TPD@bio-techne.com to enquire
- Plasmid vectors for the lentiviral expression and CRISPR-mediated knock-in of FKBP12F36V are available from Addgene.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: (R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-((-1-((2 S,4 R)-4-hydroxy-2-((-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl -1-(-2-(3,4,5-trimethoxyph)
Target: TAG Degradation Platforms
Purity: 0.98
Quantity: 5 mg
Molecular Formula: C68H90N6O14S CF3CO2H
Chemical Name or Material:
(R)-3-(3,4-Dimethoxyphenyl)-1-(2-(2-((7-((-1-((2 S,4 R)-4-hydroxy-2-((-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-7-oxoheptyl)amino)-2-oxoethoxy)phenyl)propyl -1-(-2-(3,4,5-trimethoxyph)
Target:
TAG Degradation Platforms
Purity:
0.98
Quantity:
5 mg
Molecular Formula:
C68H90N6O14S CF3CO2H
Chemical Name or Material: __
Target: __
Purity: __
Quantity: 1 mg
Molecular Formula: C23H23N3O3
Chemical Name or Material:
__
Target:
__
Purity:
__
Quantity:
1 mg
Molecular Formula:
C23H23N3O3
Chemical Name or Material: __
Target: __
Purity: __
Quantity: 5 mL
Molecular Formula: __
Chemical Name or Material:
__
Target:
__
Purity:
__
Quantity:
5 mL
Molecular Formula:
__
Chemical Name or Material: __
Target: __
Purity: __
Quantity: 500 μg
Molecular Formula: __
Chemical Name or Material:
__
Target:
__
Purity:
__
Quantity:
500 μg
Molecular Formula:
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