78-425
Tocris Bioscience™ NAMPT PROTAC™ A7
Manufacturer: Tocris Bioscience™
CAS Number: 2484876-94-8
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 78-425-Each-of-1 | In Stock | ₹ 34,532.00 |
78-425 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,532.00
GST (18%): ₹ 6,215.76
Total Price: ₹ 40,747.76
Chemical Name or Material
(2S,4R)-1-((S)-18-(tert-Butyl)-1,16-dioxo-1-(4-((4-((4-(3-(pyridin-3-ylmethyl)thioureido)phenyl)sulfonyl)piperazin-1-yl)methyl)phenyl)-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-ca
Quantity
5 mg
Molecular Formula
C58H76N10O11S3
CAS
2484876-94-8
Target
Active Degraders
Purity
0.98
Related Products
Description
- NAMPT PROTAC A7 is a potent and selective intracellular nicotinamide phosphoribosyl transferase (iNAMPT) Degrader (PROTAC™;) (IC50 of 9.5 nM against the enzymatic activity of NAMPT)
- Comprises a potent NAMPT inhibitor joined by a linker to a ligand for Von Hippel-Lindau (VHL) protein
- Proteomic analysis of global protein level changes confirms selectivity
- NAMPT PROTAC A7 decreases iNAMPT level and the secretion of extracellular NAMPT (eNAMPT) in CT26 or MC38 cells
- In CT26 tumor bearing BALB/c mice, the compound degrades tumoral NAMPT, and boosts antitumor immunity by inhibiting tumor infiltrating myeloid-derived suppressive cells
- PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Show Difference
Chemical Name or Material: (2S,4R)-1-((S)-18-(tert-Butyl)-1,16-dioxo-1-(4-((4-((4-(3-(pyridin-3-ylmethyl)thioureido)phenyl)sulfonyl)piperazin-1-yl)methyl)phenyl)-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-ca
Quantity: 5 mg
Molecular Formula: C58H76N10O11S3
CAS: 2484876-94-8
Target: Active Degraders
Purity: 0.98
Chemical Name or Material:
(2S,4R)-1-((S)-18-(tert-Butyl)-1,16-dioxo-1-(4-((4-((4-(3-(pyridin-3-ylmethyl)thioureido)phenyl)sulfonyl)piperazin-1-yl)methyl)phenyl)-5,8,11,14-tetraoxa-2,17-diazanonadecan-19-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-ca
Quantity:
5 mg
Molecular Formula:
C58H76N10O11S3
CAS:
2484876-94-8
Target:
Active Degraders
Purity:
0.98
Chemical Name or Material: __
Quantity: 100 μg
Molecular Formula: __
CAS: __
Target: __
Purity: __
Chemical Name or Material:
__
Quantity:
100 μg
Molecular Formula:
__
CAS:
__
Target:
__
Purity:
__
Chemical Name or Material: __
Quantity: 1 Set
Molecular Formula: __
CAS: __
Target: Screening Libraries
Purity: __
Chemical Name or Material:
__
Quantity:
1 Set
Molecular Formula:
__
CAS:
__
Target:
Screening Libraries
Purity:
__
Chemical Name or Material: 2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol
Quantity: 10 mg
Molecular Formula: C17H16BrF4NO2
CAS: 2165322-94-9
Target: USP28
Purity: 0.98
Chemical Name or Material:
2-[[[5-Bromo-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methoxy]phenyl]methyl]amino]ethanol
Quantity:
10 mg
Molecular Formula:
C17H16BrF4NO2
CAS:
2165322-94-9
Target:
USP28
Purity:
0.98