7121028
Tocris Bioscience™ FRAX 597
Potent group I PAK inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1286739-19-2
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Chemical Name or Material
FRAX 597
Synonym
6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Target
PAK Inhibitors
Formula Weight
558.1
Color
Yellow
Purity
>98%
CAS
1286739-19-2
Solubility
Soluble to 20mM in DMSO
Molecular Formula
C29H28ClN7OS
Physical Form
Solid
Product Type
Bioactive Small Molecule
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ FRAX 597 | Fischer Scientific | ₹ 29,090.40 | |
| | Tocris Bioscience™ FRAX 597 | Fischer Scientific | ₹ 1,21,837.44 | |
 | Selleck Chemical LLC FRAX597 5mg 1286739-19-2 | Selleck Chemical LLC | ₹ 20,226.38 | |
 | Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-[2-chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]- | Aaron Chemicals LLC | ₹ 1,967.88 - ₹ 13,005.12 |
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Description
- Potent group I PAK inhibitor (IC50 values are 8, 13 and 19 nM for PAK1, 2 and 3, respectively)
- Exhibits significant inhibition of YES1, RET, CSF1R and TEK at 100 nM, but is inactive against group II PAK isoforms (IC50 >10 μM for PAK4)
- Inhibits proliferation of pancreatic cancer and schwannoma cells in vitro and exhibits antitumor effects in mice.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: FRAX 597
Synonym: 6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Target: PAK Inhibitors
Formula Weight: 558.1
Color: Yellow
Purity: >98%
CAS: 1286739-19-2
Solubility: Soluble to 20mM in DMSO
Molecular Formula: C29H28ClN7OS
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
FRAX 597
Synonym:
6-[2-Chloro-4-(5-thiazolyl)phenyl]-8-ethyl-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7-(8H)-one
Target:
PAK Inhibitors
Formula Weight:
558.1
Color:
Yellow
Purity:
>98%
CAS:
1286739-19-2
Solubility:
Soluble to 20mM in DMSO
Molecular Formula:
C29H28ClN7OS
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Synonym: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Target: BMP and Other Activin Receptor Inhibitors
Formula Weight: 479.4
Color: Orange
Purity: 98%
CAS: 1435934-00-1
Solubility: __
Molecular Formula: C25H22N60.2 HCl
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Synonym:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Target:
BMP and Other Activin Receptor Inhibitors
Formula Weight:
479.4
Color:
Orange
Purity:
98%
CAS:
1435934-00-1
Solubility:
__
Molecular Formula:
C25H22N60.2 HCl
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: CZC 25146
Synonym: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Target: __
Formula Weight: 488.54
Color: Pale-purple
Purity: >98%
CAS: 1191911-26-8
Solubility: Soluble to 100mM in DMSO
Molecular Formula: C22H25FN6O4S
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
CZC 25146
Synonym:
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Target:
__
Formula Weight:
488.54
Color:
Pale-purple
Purity:
>98%
CAS:
1191911-26-8
Solubility:
Soluble to 100mM in DMSO
Molecular Formula:
C22H25FN6O4S
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
Chemical Name or Material: AMG 837 hemicalcium salt
Synonym: (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
Target: __
Formula Weight: 457.47
Color: White
Purity: >98%
CAS: 1291087-14-3
Solubility: Soluble to 100mM in DMSO
Molecular Formula: C26H20F3O3.?Ca
Physical Form: Solid
Product Type: Bioactive Small Molecule
Chemical Name or Material:
AMG 837 hemicalcium salt
Synonym:
(βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
Target:
__
Formula Weight:
457.47
Color:
White
Purity:
>98%
CAS:
1291087-14-3
Solubility:
Soluble to 100mM in DMSO
Molecular Formula:
C26H20F3O3.?Ca
Physical Form:
Solid
Product Type:
Bioactive Small Molecule