7161633
Tocris Bioscience™ Ibrutinib
Potent and selective BTK inhibitor (IC50= 0.5 nM)
Manufacturer: Fischer Scientific
CAS Number: 936563-96-1
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Chemical Name or Material
1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
Synonym
Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase
Formula Weight
440.5
CAS
936563-96-1
Molecular Formula
C25H24N6O2
Purity
98%
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Description
- Selective for BTK against a screening panel of kinase enzymes Inhibits autophosphorylation of BTK, phosphorylation of PLCγ, and phosphorylation of ERK (IC50 of 11 nM, 29 nM and 13 nM, respectively) Induces cytotoxicity of chronic lymphocytic leukemia (CLL) cells Reduces clinical arthritis scores in a mouse model.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
Synonym: Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase
Formula Weight: 440.5
CAS: 936563-96-1
Molecular Formula: C25H24N6O2
Purity: 98%
Chemical Name or Material:
1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
Synonym:
Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase
Formula Weight:
440.5
CAS:
936563-96-1
Molecular Formula:
C25H24N6O2
Purity:
98%
Chemical Name or Material: 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
Synonym: __
Formula Weight: 311.33
CAS: 186611-52-9
Molecular Formula: C18H17NO4
Purity: 98%
Chemical Name or Material:
1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
Synonym:
__
Formula Weight:
311.33
CAS:
186611-52-9
Molecular Formula:
C18H17NO4
Purity:
98%
Chemical Name or Material: 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Synonym: __
Formula Weight: 208.23
CAS: 651005-90-2
Molecular Formula: C10H8O3S
Purity: 98%
Chemical Name or Material:
2-Methyl-5-(2-thienyl)-3-furancarboxylic acid
Synonym:
__
Formula Weight:
208.23
CAS:
651005-90-2
Molecular Formula:
C10H8O3S
Purity:
98%
Chemical Name or Material: 4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Synonym: __
Formula Weight: 294.22
CAS: __
Molecular Formula: C11H19N5.2HCl
Purity: 98%
Chemical Name or Material:
4-[(3R)-3-Amino-1-pyrrolidinyl]-6-(1-methylethyl)-2-pyridinamine dihydrochloride
Synonym:
__
Formula Weight:
294.22
CAS:
__
Molecular Formula:
C11H19N5.2HCl
Purity:
98%