7166833
Tocris™ Galunisertib
ALK4 and ALK5 (TGFβRI) inhibitor
Manufacturer: Fischer Scientific
CAS Number: 700874-72-2
The price for this product is unavailable. Please request a quote
Chemical Name or Material
4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
Target
TGF-beta Receptor Inhibitors
Formula Weight
369.43
Purity
98%
CAS
700874-72-2
Molecular Formula
C22H19N5O
Product Type
Inhibitor
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris™ Galunisertib | Fischer Scientific | ₹ 14,134.51 | |
| | Tocris™ Galunisertib | Fischer Scientific | ₹ 53,560.56 | |
 | Medchemexpress LLC HY-13226 100mg , Galunisertib CAS:700874-72-2 Purity:>98% | Medchemexpress LLC | ₹ 22,459.50 | |
| | Medchemexpress LLC HY-13226 50mg , Galunisertib CAS:700874-72-2 Purity:>98% | Medchemexpress LLC | ₹ 13,475.70 | |
 | Medchemexpress LLC HY-13226 10mg Medchemexpress, Galunisertib CAS:700874-72-2 Purity:>98% | Medchemexpress LLC | ₹ 6,288.66 | |
 | eMolecules 4-(2-(6-METHYLPYRIDIN-2-YL)-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOL-3-YL)QUINOLINE-6-CARBOXAMIDE | 700874-72-2 | 1G | Purity: 95% | eMolecules | ₹ 1,22,290.91 | |
 | Cayman Chemical LY2157299, 700874-72-2, 10 mg | Cayman Chemical | ₹ 30,502.14 | |
 | Selleck Chemical LLC Galunisertib (LY2157299) 5mg 700874-72-2 | Selleck Chemical LLC | ₹ 17,454.24 | |
 | 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide | Aaron Chemicals LLC | ₹ 941.16 - ₹ 88,896.84 |
Related Products
Description
- ALK4 and ALK5 (TGFβRI) inhibitor (IC50 values are 77.7 and 172 nM, respectively)
- Also inhibits a range of other kinases with submicromolar IC50s including MINK, TGFβRII, ALK6 and ACVR2B
- Inhibits TGFβ-induced SMAD phosphorylation in cancer cell lines in vitro and in vivo
- Also reverses TGFβ-mediated suppression of T cell proliferation
- Prevents TGFβ-mediated EMT and cell migration in vitro and exhibits antitumor efficacy in vivo
- Used as component of growth media for urothelial organoids
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: 4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
Target: TGF-beta Receptor Inhibitors
Formula Weight: 369.43
Purity: 98%
CAS: 700874-72-2
Molecular Formula: C22H19N5O
Product Type: Inhibitor
Chemical Name or Material:
4-[5,6-Dihydro-2-(6-methyl-2-pyridinyl)-4 H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
Target:
TGF-beta Receptor Inhibitors
Formula Weight:
369.43
Purity:
98%
CAS:
700874-72-2
Molecular Formula:
C22H19N5O
Product Type:
Inhibitor
Chemical Name or Material: 4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2 H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1 H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Target: Bcl-2 Family Inhibitors
Formula Weight: 868.45
Purity: 98%
CAS: 1257044-40-8
Molecular Formula: C45H50ClN7O7S
Product Type: Inhibitor
Chemical Name or Material:
4-[4-[[2-(4-Chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[3-nitro-4-[[(tetrahydro-2 H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1 H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide
Target:
Bcl-2 Family Inhibitors
Formula Weight:
868.45
Purity:
98%
CAS:
1257044-40-8
Molecular Formula:
C45H50ClN7O7S
Product Type:
Inhibitor
Chemical Name or Material: __
Target: __
Formula Weight: 428.92
Purity: 98%
CAS: __
Molecular Formula: C21H25ClN6O2
Product Type: Inhibitor
Chemical Name or Material:
__
Target:
__
Formula Weight:
428.92
Purity:
98%
CAS:
__
Molecular Formula:
C21H25ClN6O2
Product Type:
Inhibitor
Chemical Name or Material: __
Target: __
Formula Weight: __
Purity: __
CAS: __
Molecular Formula: __
Product Type: __
Chemical Name or Material:
__
Target:
__
Formula Weight:
__
Purity:
__
CAS:
__
Molecular Formula:
__
Product Type:
__