7235823
Tocris™ Bortezomib
High affinity proteasome inhibitor
Manufacturer: Fischer Scientific
CAS Number: 179324-69-7
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Chemical Name or Material
B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target
Proteasome Inhibitors
Purity
0.98
CAS
179324-69-7
Molecular Formula
C19H25BN4O4
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Description
- Bortezomib is a high affinity proteasome inhibitor (Ki = 0.6 nM)
- Inhibits growth of multiple myeloma (MM) cell lines (IC50 values in <50 nM range); induces apoptosis in MM cell lines and MM patient derived cells, including p53 mutant cell lines
- Decreases adherence of MM cells lines to bone marrow stromal cells (BMSCs)
- Acts synergistically with dexamethasone (Cat
- No
- 1126)
- Also cytotoxic in MCF-7 breast cancer cell line (IC50 = 50 nM).
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target: Proteasome Inhibitors
Purity: 0.98
CAS: 179324-69-7
Molecular Formula: C19H25BN4O4
Chemical Name or Material:
B-[(1 R)-3-Methyl-1-[[(2 S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid
Target:
Proteasome Inhibitors
Purity:
0.98
CAS:
179324-69-7
Molecular Formula:
C19H25BN4O4
Chemical Name or Material: [2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
Target: Adenosine A1 Receptor Modulators
Purity: 0.98
CAS: 1018830-99-3
Molecular Formula: C18H12F3NOS
Chemical Name or Material:
[2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone
Target:
Adenosine A1 Receptor Modulators
Purity:
0.98
CAS:
1018830-99-3
Molecular Formula:
C18H12F3NOS
Chemical Name or Material: N-[(1 S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5 H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide hydrochloride
Target: NPY Receptor Antagonists
Purity: 0.98
CAS: 2624332-04-1
Molecular Formula: C49H57N11O6.HCl
Chemical Name or Material:
N-[(1 S)-4-[(Aminoiminomethyl)amino]-1-[[[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]amino]carbonyl]butyl]-1-[2-[4-(6,11-dihydro-6-oxo-5 H-dibenz[b,e]azepin-11-yl)-1-piperazinyl]-2-oxoethyl]-cyclopentaneacetamide hydrochloride
Target:
NPY Receptor Antagonists
Purity:
0.98
CAS:
2624332-04-1
Molecular Formula:
C49H57N11O6.HCl
Chemical Name or Material: __
Target: __
Purity: ≥90%
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Molecular Formula: __
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Purity:
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