7249494
Tocris Bioscience™ EED 226
Potent and selective EED inhibitor
Manufacturer: Fischer Scientific
CAS Number: 2083627-02-3
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Chemical Name or Material
N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS
2083627-02-3
Target
EED
Molecular Formula
C17H15N5O3S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ EED 226 | Fischer Scientific | ₹ 16,145.17 | |
| | Tocris Bioscience™ EED 226 | Fischer Scientific | ₹ 67,763.52 | |
 | Medchemexpress LLC HY-101117 25mg , EED226 CAS:2083627-02-3 Purity:>98% | Medchemexpress LLC | ₹ 14,823.27 | |
 | Thermo Scientific™ EED226, 95% | Thermo Scientific™ | ₹ 52,277.16 | |
 | Medchemexpress LLC HY-101117 10mg Medchemexpress, EED226 CAS:2083627-02-3 Purity:>98% | Medchemexpress LLC | ₹ 8,893.96 |
Related Products
Description
- EED 226 is a potent (IC50 = 23.4 nM) and selective EED inhibitor
- It inhibits PRC2 activity by binding to the H3K27me3 pocket of EED
- The compound shows selectivity for PRC2 complex over protein methyltransferases, kinases, and other protein classes
- In vitro , EED 226 regulates histone H3K27 methylation and PRC2 target gene expression
- In vivo , it induces tumor regression in a mouse xenograft model
- EED 226 is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Compare Similar Items
Show Difference
Chemical Name or Material: N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS: 2083627-02-3
Target: EED
Molecular Formula: C17H15N5O3S
Chemical Name or Material:
N-(2-Furanylmethyl)-8-[4-(methylsulfonyl)phenyl]-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
CAS:
2083627-02-3
Target:
EED
Molecular Formula:
C17H15N5O3S
Chemical Name or Material: 3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
CAS: 612542-14-0
Target: Smoothened
Molecular Formula: C28H26ClF2N3OS
Chemical Name or Material:
3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
CAS:
612542-14-0
Target:
Smoothened
Molecular Formula:
C28H26ClF2N3OS
Chemical Name or Material: rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
CAS: 1035270-39-3
Target: FGF Receptor Inhibitors
Molecular Formula: C26H33N5O3
Chemical Name or Material:
rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
CAS:
1035270-39-3
Target:
FGF Receptor Inhibitors
Molecular Formula:
C26H33N5O3
Chemical Name or Material: 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS: 2230820-11-6
Target: DNA-dependent Protein Kinase Inhibitors
Molecular Formula: C18H20N8O2
Chemical Name or Material:
7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS:
2230820-11-6
Target:
DNA-dependent Protein Kinase Inhibitors
Molecular Formula:
C18H20N8O2