7249496
Tocris Bioscience™ AZD 4547
Potent and selective FGFR inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1035270-39-3
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Chemical Name or Material
rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
CAS
1035270-39-3
Target
FGF Receptor Inhibitors
Molecular Formula
C26H33N5O3
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ AZD 4547 | Fischer Scientific | ₹ 22,373.94 | |
| | Tocris Bioscience™ AZD 4547 | Fischer Scientific | -- | |
 | Medchemexpress LLC HY-13330 50mg , AZD4547 CAS:1035270-39-3 Purity:>98% | Medchemexpress LLC | ₹ 16,620.03 | |
 | Biotang Inc AZD4547, Free Base, > 99%, 50MG, M.W. 463.57, C26H33N5O3, CAS#1035270-39-3. | Biotang Inc | ₹ 24,974.96 | |
 | Selleck Chemical LLC AZD4547 10mg 1035270-39-3 | Selleck Chemical LLC | ₹ 20,226.38 | |
| | eMolecules Ambeed / rel-N-(5-(35-Dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3R5S)-35-dimethylpiperazin-1-yl)benzamide / 1mg / 713090386 / A868383 / / 1035270-39-3 / MFCD22580423 / 463.582 / C26H33N5O3 | eMolecules | ₹ 2,065.42 | |
 | Medchemexpress LLC HY-13330 10mg Medchemexpress, AZD4547 CAS:1035270-39-3 Purity:>98% | Medchemexpress LLC | ₹ 8,265.10 |
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Description
- AZD 4547 is a potent and selective FGFR1, FGFR3 and FGFR2 tyrosine kinase inhibitor (IC50 values are 0.2 1.8, and 2.5 nM, respectively)
- It shows selectivity for FGFR across a range of unrelated tyrosine and serine/threonine kinases, including IGFR (>2,900-fold), CDK2 (>50,000-fold), and p38 (>50,000-fold)
- In vitro , it has antiproliferative effects on tumor cell lines with deregulated FGFR expression
- In vivo , AZD 4547 exhibits dose-dependent inhibition of tumor growth in an FGFR-driven human tumor xenograft mice model
- It suppresses osteoclastogenesis and tumor-induced osteolysis in an orthotopic breast cancer bone metastasis mouse model
- AZD 4547 is orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Compare Similar Items
Show Difference
Chemical Name or Material: rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
CAS: 1035270-39-3
Target: FGF Receptor Inhibitors
Molecular Formula: C26H33N5O3
Chemical Name or Material:
rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
CAS:
1035270-39-3
Target:
FGF Receptor Inhibitors
Molecular Formula:
C26H33N5O3
Chemical Name or Material: 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS: 2230820-11-6
Target: DNA-dependent Protein Kinase Inhibitors
Molecular Formula: C18H20N8O2
Chemical Name or Material:
7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
CAS:
2230820-11-6
Target:
DNA-dependent Protein Kinase Inhibitors
Molecular Formula:
C18H20N8O2
Chemical Name or Material: __
CAS: 956697-53-3
Target: Smoothened
Molecular Formula: C26H26F3N3O3
Chemical Name or Material:
__
CAS:
956697-53-3
Target:
Smoothened
Molecular Formula:
C26H26F3N3O3
Chemical Name or Material: Poly[imino(1,2-ethanediyl)] hydrochloride
CAS: 49553-93-7
Target: Transfection Reagent
Molecular Formula: __
Chemical Name or Material:
Poly[imino(1,2-ethanediyl)] hydrochloride
CAS:
49553-93-7
Target:
Transfection Reagent
Molecular Formula:
__