7250150
Tocris Bioscience™ C28
Potent LMTK3 inhibitor
Manufacturer: Fischer Scientific
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Chemical Name or Material
6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Target
LMTK3
Molecular Formula
C18H11F3N4O
Purity
0.98
Related Products
Description
- C28 is a potent lemur tyrosine kinase 3 (LMTK3) inhibitor (IC50 = 67 nM)
- Disrupts interaction of LMTK3 and HSP90 leading to degradation of LMTK3
- Also inhibits CLK, DYRK1α, IRAK4 and HIPK2 (IC50 values are 5 nM, 6 nM, 41 nM and 48 nM respectively)
- C28 inhibits growth and increases apoptosis in breast cancer cell lines (IC50 = 6.5-14.77 μM) and reduces growth of tumors in xenograft and transgenic mouse models of breast cancer
- Also reduces levels of ERα.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Target: LMTK3
Molecular Formula: C18H11F3N4O
Purity: 0.98
Chemical Name or Material:
6-(Pyridin-4-yl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine
Target:
LMTK3
Molecular Formula:
C18H11F3N4O
Purity:
0.98
Chemical Name or Material: N-[(1-Methyl-1 H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine
Target: Hydrolase Inhibitors
Molecular Formula: C15H22N6
Purity: 0.98
Chemical Name or Material:
N-[(1-Methyl-1 H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)-2-pyrimidinamine
Target:
Hydrolase Inhibitors
Molecular Formula:
C15H22N6
Purity:
0.98
Chemical Name or Material: 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1 H-indole-6-carboxamide
Target: STING Agonists
Molecular Formula: C25H19ClF4N2O2
Purity: 0.98
Chemical Name or Material:
1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1 H-indole-6-carboxamide
Target:
STING Agonists
Molecular Formula:
C25H19ClF4N2O2
Purity:
0.98
Chemical Name or Material: 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Target: CD117/c-kit
Molecular Formula: C28H30N6OS
Purity: 0.98
Chemical Name or Material:
4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
Target:
CD117/c-kit
Molecular Formula:
C28H30N6OS
Purity:
0.98