7250169
Tocris Bioscience™ Verubecestat
BACE1 and BACE2 inhibitor
Manufacturer: Fischer Scientific
CAS Number: 1286770-55-5
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Chemical Name or Material
N-[3-[(5 R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2 H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Target
Secretase Inhibitors
Purity
0.98
CAS
1286770-55-5
Molecular Formula
C17H17F2N5O3S
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ Verubecestat | Fischer Scientific | ₹ 15,582.19 | |
| | Tocris Bioscience™ Verubecestat | Fischer Scientific | ₹ 65,405.49 | |
 | Medchemexpress LLC HY-16759 100mg , Verubecestat CAS:1286770-55-5 Purity:>98% | Medchemexpress LLC | ₹ 40,427.10 | |
 | eMolecules Ambeed / (R)-N-(3-(3-Amino-25-dimethyl-11-dioxido-56-dihydro-2H-124-thiadiazin-5-yl)-4-fluorophenyl)-5-fluoropicolinamide / 1mg / 534567618 / A262054 / / 1286770-55-5 / MFCD28963974 / 409.410 / C17H17F2N5O3S | eMolecules | ₹ 4,693.82 | |
 | 2-Pyridinecarboxamide, N-[3-[(5R)-3-amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro- | Aaron Chemicals LLC | ₹ 1,882.32 - ₹ 57,667.44 | |
 | 1286770-55-5 | Verubecestat Free Base | A2B Chem | ₹ 2,310.12 - ₹ 23,272.32 |
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Description
- Verubecestat is a high affinity and selective β-secretase 1 (BACE1) and its homolog BACE2 inhibitor (Ki of 2.2 nM and 0.38 nM respectively)
- It exhibits no inhibition of cathepsin D, cathepsin E, pepsin, or renin
- Verubecestat potently reduces Aβ40 formation in HEK293 APPSwe/Lon cells (IC50 = 2.1 nM)
- Verubecestat significantly lowers CSF and brain Aβ levels in rats
- Orally bioavailable.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
Show Difference
Chemical Name or Material: N-[3-[(5 R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2 H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Target: Secretase Inhibitors
Purity: 0.98
CAS: 1286770-55-5
Molecular Formula: C17H17F2N5O3S
Chemical Name or Material:
N-[3-[(5 R)-3-Amino-5,6-dihydro-2,5-dimethyl-1,1-dioxido-2 H-1,2,4-thiadiazin-5-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide
Target:
Secretase Inhibitors
Purity:
0.98
CAS:
1286770-55-5
Molecular Formula:
C17H17F2N5O3S
Chemical Name or Material: N-(5-Chloro-2-pyridinyl)-2-(5 H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
Target: Molecular Glues
Purity: 0.98
CAS: 296771-07-8
Molecular Formula: C16H11ClN6OS
Chemical Name or Material:
N-(5-Chloro-2-pyridinyl)-2-(5 H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
Target:
Molecular Glues
Purity:
0.98
CAS:
296771-07-8
Molecular Formula:
C16H11ClN6OS
Chemical Name or Material: 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
Target: Hedgehog Signaling Inhibitors
Purity: 0.98
CAS: 879085-55-9
Molecular Formula: C19H14Cl2N2O3S
Chemical Name or Material:
2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide
Target:
Hedgehog Signaling Inhibitors
Purity:
0.98
CAS:
879085-55-9
Molecular Formula:
C19H14Cl2N2O3S
Chemical Name or Material: 1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1 R,2 S)-2-vinylcyclopropane-1-carboxamide
Target: CRISPR Reagents
Purity: 0.98
CAS: 630420-16-5
Molecular Formula: C35H46ClN5O9S
Chemical Name or Material:
1-[[N-tert-Butoxycarbonyl-L-tert-leucyl-trans-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-L-prolyl]amino]-N-(cyclopropylsulfonyl)-(1 R,2 S)-2-vinylcyclopropane-1-carboxamide
Target:
CRISPR Reagents
Purity:
0.98
CAS:
630420-16-5
Molecular Formula:
C35H46ClN5O9S