M3512

(±)-Miconazole nitrate salt

imidazole antibiotic

Manufacturer: Sigma Aldrich

CAS Number: 22832-87-7

Synonym(S): 1-(2,4-Dichloro-β-[(2,4-dichlorobenzyl)oxy]phenethyl)imidazole

Select a Size

Pack Size SKU Availability Price
1 G M3512-1-G In Stock ₹ 6,884.70
5 G M3512-5-G In Stock ₹ 18,889.63
25 G M3512-25-G In Stock ₹ 76,500.28

M3512 - 1 G

₹ 6,884.70

In Stock

Quantity

1

Base Price: ₹ 6,884.70

GST (18%): ₹ 1,239.246

Total Price: ₹ 8,123.946

Quality Level

200

optical activity

[α]/D ±0.10° (Specific Rotation (BP))

color

white to off-white

antibiotic activity spectrum

fungimycobacteria

Mode of action

enzyme | inhibits

SMILES string

ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O

InChI

1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)

InChI key

MCCACAIVAXEFAL-UHFFFAOYSA-N

Other Options

Image Product Name Manufacturer Price Range
11-101-3599
(±)-Miconazole nitrate salt Pharmaceutical Secondary Standard, MilliporeSigma™ Supelco™
MilliporeSigma Supelco ₹ 19,593.24
PHR1163
(±)-Miconazole nitrate salt
Supelco ₹ 17,742.18
1443500
Miconazole nitrate
Sigma Aldrich ₹ 40,756.13
M1900000
Miconazole nitrate
Sigma Aldrich ₹ 16,107.60
BP253
Miconazole nitrate
Sigma Aldrich ₹ 23,533.55
M3512
(±)-Miconazole nitrate salt
Sigma Aldrich ₹ 6,884.70 - ₹ 76,500.28
CS-2881
Miconazole (nitrate)
ChemScene ₹ 4,705.80 - ₹ 9,069.36
AI45434
22832-87-7 | 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole; nitric acid
A2B Chem ₹ 1,368.96 - ₹ 44,919.00

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Description

  • General description: Chemical structure: imidazole
  • Application: Miconazole is an imidazole antifungal agent that is used topically and by intravenous infusion. It is used to inhibit cytochrome P450 [1] and to study automated luminescence-based cytochrome P450 profiling[2].
  • Biochem/physiol Actions: Miconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary for ergosterol biosynthesis. The inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with phospholipids in the cell membrane, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and interfere with triglyceride and phospholipid biosynthesis.
  • Preparation Note: Sparingly soluble in methanol, slightly soluble in ethanol. Very slightly soluble in water.

SAFETY INFORMATION

Pictograms

GHS07

Signal Word

Warning

Hazard Statements

H302,H317

Precautionary Statements

P280 - P301 + P312 + P330 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Sigma Aldrich

M3512

imidazole antibiotic...


Quality Level:
200

optical activity:
[α]/D ±0.10° (Specific Rotation (BP))

color:
white to off-white

antibiotic activity spectrum:
fungimycobacteria

Mode of action:
enzyme | inhibits

SMILES string:
ClC1=CC(Cl)=CC=C1C(OCC2=CC=C(Cl)C=C2Cl)CN3C=CN=C3.[O-][N+](O)=O

InChI:
1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)

InChI key:
MCCACAIVAXEFAL-UHFFFAOYSA-N

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AEOVEGJBKQQFOP-DDVLFWKVSA-L

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InChI key:
AEOVEGJBKQQFOP-DDVLFWKVSA-L

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