PC3451SET
MilliporeSigma™ Orexin A (14-33) (Ab-1), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set
Manufacturer: MilliporeSigma™
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Antigen
Orexin A (14-33) (Ab-1)
Classification
Polyclonal
Formulation
100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen
a synthetic peptide (CRLYELLHGAGNHAAGILTL) corresponding to amino acids 14-33 of human orexin A
Regulatory Status
RUO
Test Specificity
Recognizes orexin A in mouse and rat brain. Supplied with a control peptide.
Target Species
Bovine, Human, Mouse, Rat
Form
Purified
Applications
ELISA, Immunofluorescence, Immunohistochemistry (Frozen)
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
1 Set
Primary or Secondary
Primary
Includes
100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage
2°C to 8°C
Isotype
IgG
Related Products
Description
- Specifically detects Orexin A (14-33) (Ab-1) Clone: in Bovine, Human, Mouse, Rat samples, and it is validated for ELISA, Immunofluorescence, Immunohistochemistry (Frozen) The hypothalamus has been shown to play a central role in the regulation of energy homeostasis and in the control of feeding behavior
- Two homologous peptides have recently been identified for which the message and protein have been localized to the lateral hypothalamus
- Orexin A (hypocretin 1), a 33 amino acid peptide, and orexin B (hypocretin 2), a 28 amino acid peptide, are both encoded by a single mRNA transcript
- These peptides stimulate food consumption in a dose-dependent manner when administered intracerebroventricularly, and precursor mRNA levels are upregulated upon fasting
- In addition to the orexins (hypocretins), two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides
- Competitive radioligand binding assays suggest that the orexin receptor-1 is selective for orexin A, while orexin receptor-2 is nonselective for both peptides.
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Antigen: Orexin A (14-33) (Ab-1)
Classification: Polyclonal
Formulation: 100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen: a synthetic peptide (CRLYELLHGAGNHAAGILTL) corresponding to amino acids 14-33 of human orexin A
Regulatory Status: RUO
Test Specificity: Recognizes orexin A in mouse and rat brain. Supplied with a control peptide.
Target Species: Bovine, Human, Mouse, Rat
Form: Purified
Applications: ELISA, Immunofluorescence, Immunohistochemistry (Frozen)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 1 Set
Primary or Secondary: Primary
Includes: 100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage: 2°C to 8°C
Isotype: IgG
Antigen:
Orexin A (14-33) (Ab-1)
Classification:
Polyclonal
Formulation:
100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen:
a synthetic peptide (CRLYELLHGAGNHAAGILTL) corresponding to amino acids 14-33 of human orexin A
Regulatory Status:
RUO
Test Specificity:
Recognizes orexin A in mouse and rat brain. Supplied with a control peptide.
Target Species:
Bovine, Human, Mouse, Rat
Form:
Purified
Applications:
ELISA, Immunofluorescence, Immunohistochemistry (Frozen)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
1 Set
Primary or Secondary:
Primary
Includes:
100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage:
2°C to 8°C
Isotype:
IgG
Antigen: Serotonin 3 (5-HT3) Receptor (444-457)
Classification: Polyclonal
Formulation: 25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen: a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
Regulatory Status: RUO
Test Specificity: Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Target Species: Mouse, Rat
Form: Purified
Applications: Immunohistochemistry (Frozen)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 1 Set
Primary or Secondary: Primary
Includes: 25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage: 2°C to 8°C
Isotype: IgG
Antigen:
Serotonin 3 (5-HT3) Receptor (444-457)
Classification:
Polyclonal
Formulation:
25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen:
a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
Regulatory Status:
RUO
Test Specificity:
Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Target Species:
Mouse, Rat
Form:
Purified
Applications:
Immunohistochemistry (Frozen)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
1 Set
Primary or Secondary:
Primary
Includes:
25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage:
2°C to 8°C
Isotype:
IgG
Antigen: PhosphoDetect™ p53 (pSer15)
Classification: Polyclonal
Formulation: In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.
Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Ser15phosphorylation site of human p53, conjugated to KLH
Regulatory Status: RUO
Test Specificity: Recognizes the ∽53kDa p53 protein phosphorylated at Ser15in PC12 or HeLa cells treated with DNA damaging agents. Does not recognize unphosphorylated p53.
Target Species: Human, Mouse, Rat
Form: Undiluted
Applications: Immunoprecipitation
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 50 μL
Primary or Secondary: Primary
Includes: __
Content And Storage: −20°C
Isotype: IgG
Antigen:
PhosphoDetect™ p53 (pSer15)
Classification:
Polyclonal
Formulation:
In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.
Immunogen:
a synthetic phosphopeptide corresponding to amino acids surrounding the Ser15phosphorylation site of human p53, conjugated to KLH
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽53kDa p53 protein phosphorylated at Ser15in PC12 or HeLa cells treated with DNA damaging agents. Does not recognize unphosphorylated p53.
Target Species:
Human, Mouse, Rat
Form:
Undiluted
Applications:
Immunoprecipitation
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
50 μL
Primary or Secondary:
Primary
Includes:
__
Content And Storage:
−20°C
Isotype:
IgG
Antigen: Cathepsin B
Classification: Polyclonal
Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen: purified human liver cathepsin B
Regulatory Status: RUO
Test Specificity: Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 100 μg
Primary or Secondary: Primary
Includes: __
Content And Storage: 2°C to 8°C
Isotype: IgG
Antigen:
Cathepsin B
Classification:
Polyclonal
Formulation:
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen:
purified human liver cathepsin B
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
100 μg
Primary or Secondary:
Primary
Includes:
__
Content And Storage:
2°C to 8°C
Isotype:
IgG