PC3471SET
MilliporeSigma™ Serotonin 3 (5-HT3) Receptor (444-457), Rabbbit Polyclonal, ChIP Validated Antibody and Primer Set
Manufacturer: MilliporeSigma™
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Antigen
Serotonin 3 (5-HT3) Receptor (444-457)
Classification
Polyclonal
Formulation
25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen
a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
Regulatory Status
RUO
Test Specificity
Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Target Species
Mouse, Rat
Form
Purified
Applications
Immunohistochemistry (Frozen)
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
1 Set
Primary or Secondary
Primary
Includes
25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage
2°C to 8°C
Isotype
IgG
Related Products
Description
- Specifically detects Serotonin 3 (5-HT 3 ) Receptor (444-457) Clone: in Mouse, Rat samples, and it is validated for Immunohistochemistry (Frozen) The monoamine serotonin (5-hydroxytryptamine) mediates a variety of physiological actions by binding to a number of distinct receptors, pharmacologically classified into several major groups which differ in tissue and cellular localization, affinity for serotonin, and second messenger pathways
- The majority of these receptors stimulate a GTP-binding protein upon agonist stimulation and couple to adenylate cyclase or phospholipase C
- In contrast, the 5-HT 3 receptor is a ligand-gated ion channel that mediates a fast excitatory response
- This receptor is a member of the superfamily of ligand-gated ion channels related to the nicotinic, GABA A and NMDA receptors
- Although the 5-HT 3 receptor was initially identified from the neuroblastoma cell line NCB-20, radioligand binding studies and in situ hybridization studies have localized the 5-HT 3 receptor to a unique distribution of neurons, supporting possible roles for the receptor in cognition and sensory input
- Recent immunohistochemical analysis of the rat brain revealed a broad distribution of 5-HT 3 immunoreactivity, primarily including interneurons and motor neurons.
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Antigen: Serotonin 3 (5-HT3) Receptor (444-457)
Classification: Polyclonal
Formulation: 25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen: a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
Regulatory Status: RUO
Test Specificity: Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Target Species: Mouse, Rat
Form: Purified
Applications: Immunohistochemistry (Frozen)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 1 Set
Primary or Secondary: Primary
Includes: 25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage: 2°C to 8°C
Isotype: IgG
Antigen:
Serotonin 3 (5-HT3) Receptor (444-457)
Classification:
Polyclonal
Formulation:
25μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Immunogen:
a synthetic peptide (SLEKRDEMREVARD) corresponding to amino acids 444-457 of rat serotonin (5-HT3) receptor, conjugated to KLH
Regulatory Status:
RUO
Test Specificity:
Recognizes the serotonin 3 (5-HT3) receptor in mouse and rat brain tissue. Supplied with a control peptide.
Target Species:
Mouse, Rat
Form:
Purified
Applications:
Immunohistochemistry (Frozen)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
1 Set
Primary or Secondary:
Primary
Includes:
25μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide.
Content And Storage:
2°C to 8°C
Isotype:
IgG
Antigen: PhosphoDetect™ p53 (pSer15)
Classification: Polyclonal
Formulation: In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.
Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Ser15phosphorylation site of human p53, conjugated to KLH
Regulatory Status: RUO
Test Specificity: Recognizes the ∽53kDa p53 protein phosphorylated at Ser15in PC12 or HeLa cells treated with DNA damaging agents. Does not recognize unphosphorylated p53.
Target Species: Human, Mouse, Rat
Form: Undiluted
Applications: Immunoprecipitation
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 50 μL
Primary or Secondary: Primary
Includes: __
Content And Storage: −20°C
Isotype: IgG
Antigen:
PhosphoDetect™ p53 (pSer15)
Classification:
Polyclonal
Formulation:
In 150mM NaCl, 10mM sodium HEPES, 100μg/mL BSA, 50% glycerol, pH 7.5.
Immunogen:
a synthetic phosphopeptide corresponding to amino acids surrounding the Ser15phosphorylation site of human p53, conjugated to KLH
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽53kDa p53 protein phosphorylated at Ser15in PC12 or HeLa cells treated with DNA damaging agents. Does not recognize unphosphorylated p53.
Target Species:
Human, Mouse, Rat
Form:
Undiluted
Applications:
Immunoprecipitation
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
50 μL
Primary or Secondary:
Primary
Includes:
__
Content And Storage:
−20°C
Isotype:
IgG
Antigen: Cathepsin B
Classification: Polyclonal
Formulation: In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen: purified human liver cathepsin B
Regulatory Status: RUO
Test Specificity: Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 100 μg
Primary or Secondary: Primary
Includes: __
Content And Storage: 2°C to 8°C
Isotype: IgG
Antigen:
Cathepsin B
Classification:
Polyclonal
Formulation:
In 0.05M sodium phosphate buffer, 0.2% gelatin.
Immunogen:
purified human liver cathepsin B
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽43kDa latent and the ∽31kDa active forms of cathepsin B in breast carcinoma tissues.
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
100 μg
Primary or Secondary:
Primary
Includes:
__
Content And Storage:
2°C to 8°C
Isotype:
IgG
Antigen: Vanilloid Receptor Like Protein-1 (744-761)
Classification: Polyclonal
Formulation: 100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Immunogen: a synthetic peptide (KNSASEEDHLPLQVLQSP) corresponding to amino acids 744-761 of rat vanilloid receptor like protein 1, conjugated to KLH
Regulatory Status: RUO
Test Specificity: Recognizes the ∽98kDa (doublet) vanilloid receptor like protein-1 in rat spinal cord extract. Supplied with a control peptide (100μg size only).
Target Species: Mouse, Rat
Form: Purified
Applications: Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 1 Set
Primary or Secondary: Primary
Includes: 100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Content And Storage: 2°C to 8°C
Isotype: IgG
Antigen:
Vanilloid Receptor Like Protein-1 (744-761)
Classification:
Polyclonal
Formulation:
100μg antibody in 0.05 M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Immunogen:
a synthetic peptide (KNSASEEDHLPLQVLQSP) corresponding to amino acids 744-761 of rat vanilloid receptor like protein 1, conjugated to KLH
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽98kDa (doublet) vanilloid receptor like protein-1 in rat spinal cord extract. Supplied with a control peptide (100μg size only).
Target Species:
Mouse, Rat
Form:
Purified
Applications:
Immunoblot, Immunocytochemistry, Immunohistochemistry (Frozen)
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
1 Set
Primary or Secondary:
Primary
Includes:
100μg antibody in 0.05M sodium phosphate buffer, 0.2% gelatin and 25μg lyophilized control peptide (immunogen) (100μg size only).
Content And Storage:
2°C to 8°C
Isotype:
IgG