3971464
MEK1 Mouse, Unlabeled, Clone: 25/MEK1, BD
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
MEK1
Concentration
250μg/mL
Classification
Monoclonal
Host Species
Mouse
Research Discipline
Cell Biology
Formulation
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype
IgG2a
Purification Method
Affinity Purified
Clone
25/MEK1
Applications
Western Blot
Conjugate
Unconjugated
Regulatory Status
RUO
Target Species
Canine, Chicken, Frog, Human, Mouse, Rat
Immunogen
Human MEK1 aa. 2-124
Primary or Secondary
Primary
Content And Storage
Store undiluted at -20°C.
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Description
- MEK1 (MapK/ERK Kinase 1) is a 45kDa member of the MEK family of dual specificity kinases
- MEK is activated by a variety of cellular serine/threonine kinases including c-Raf, A-Raf, c-mos, and MEK Kinase-1
- Activated MEK phosphorylates MAP kinase (ERK) at threonine and tyrosine residues
- This results in activation of ERK and its signaling pathway
- MEK is highly specific for ERK and various MEKs preferentially phosphorylate individual ERK isoforms
- MEK1 only activates ERK1 and ERK2
- This specificity may result from variations in ERK regions that are known as the phosphorylation lip and kinase backbone
- MEK's localization is cytoplasmic, but mitogenic stimulation induces a mass translocation to the nucleus
- Mechanisms behind this nuclear translocation remain unknown
- However, MEK contains an N-terminal nuclear export signal (NES) that mediates its rapid exodus from the nucleus and restores its unstimulated cellular distribution
- Host Species: Mouse Clone: 25 Isotype: IgG2a Species Reactivity: Human Immunogen: Human MEK1 aa
- 2-124 Formula Weight [Chemical]: 45kDa Bioimaging, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Compare Similar Items
Show Difference
Antigen: MEK1
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG2a
Purification Method: Affinity Purified
Clone: 25/MEK1
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Frog, Human, Mouse, Rat
Immunogen: Human MEK1 aa. 2-124
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
MEK1
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG2a
Purification Method:
Affinity Purified
Clone:
25/MEK1
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Frog, Human, Mouse, Rat
Immunogen:
Human MEK1 aa. 2-124
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: Nedd4
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 15
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Mouse
Immunogen: Mouse Nedd4 aa. 173-262
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
Nedd4
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
15
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Mouse
Immunogen:
Mouse Nedd4 aa. 173-262
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: p120 Catenin
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 98
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Human, Mouse, Rat
Immunogen: Mouse pp120 aa. 326-632
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
p120 Catenin
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
98
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Human, Mouse, Rat
Immunogen:
Mouse pp120 aa. 326-632
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.
Antigen: p120 Catenin
Concentration: 250μg/mL
Classification: Monoclonal
Host Species: Mouse
Research Discipline: Cell Biology
Formulation: Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype: IgG1
Purification Method: Affinity Purified
Clone: 98
Applications: Western Blot
Conjugate: Unconjugated
Regulatory Status: RUO
Target Species: Canine, Chicken, Human, Mouse, Rat
Immunogen: Mouse pp120 aa. 326-632
Primary or Secondary: Primary
Content And Storage: Store undiluted at -20°C.
Antigen:
p120 Catenin
Concentration:
250μg/mL
Classification:
Monoclonal
Host Species:
Mouse
Research Discipline:
Cell Biology
Formulation:
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Isotype:
IgG1
Purification Method:
Affinity Purified
Clone:
98
Applications:
Western Blot
Conjugate:
Unconjugated
Regulatory Status:
RUO
Target Species:
Canine, Chicken, Human, Mouse, Rat
Immunogen:
Mouse pp120 aa. 326-632
Primary or Secondary:
Primary
Content And Storage:
Store undiluted at -20°C.