50-177-30
CD62E (E-selectin) Monoclonal Antibody (CL2), eBioscience™, Invitrogen™
Manufacturer: Invitrogen
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | 50-177-30-Each-of-1 | In Stock | ₹ 20,619.96 |
50-177-30 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 20,619.96
GST (18%): ₹ 3,711.593
Total Price: ₹ 24,331.553
Antigen
CD62E (E-selectin)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with no preservative; pH 7.2-7.4
Gene Accession No.
P16581
Gene Symbols
SELE
Immunogen
Rec. Human CD62E (E-selectin)
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone
CL2
Conjugate
Unconjugated
Gene
SELE
Gene Alias
CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Host Species
Mouse
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6401
Content And Storage
4° C
Form
Liquid
Related Products
Description
- Description: E-Selectin (CL-2) is a mouse monoclonal antibody raised against E-Selectinof human origin
- CL2, but not CL37, blocks binding of leukocytes to E-selectin
- Endothelial Leukocyte Adhesion Molecule-1 belongs to the selectin family of adhesion molecules
- Together with L-selectin and P-selectin, E-selectin mediates the initial interactions of leukocytes and platelets with endothelial cells
- Molecular structure: The extracellular part of all selectins consists of an aminoterminal c-type lectin domain which specifically binds to carbohydrate ligands
- This is followed by an EGF-like domain, and, in the case of E-selectin, by 6 short consensus repeats
- The transmembrane portion of the molecule is followed by a short cytoplasmic tail
- Selectins guide non-activated polymorphonuclear cells to the areas of inflammation in creating first, loose contacts with the endothelial layer
- Together with P-selectin, E-selectin is expressed on cytokine-activated endothelial cells, and contributes to the adhesion of still resting leukocytes to the endothelium
- This initial binding event is an essential prerequisite for the activation of the immune cells via different inflammatory mediators
- In contrast to P-selectin, E-selectin is maximally expressed 2-4 hours after cell activation
- Within the next 24-48 hours E-selectin is again eliminated from the cytoplasmic membrane by shedding into the circulation
- Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes
- In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation
- This response is immediate and involves a cascade of adhesion receptors
- At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade
- Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium
- E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines
- In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signaling cascade
- E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations.
Compare Similar Items
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Antigen: CD62E (E-selectin)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with no preservative; pH 7.2-7.4
Gene Accession No.: P16581
Gene Symbols: SELE
Immunogen: Rec. Human CD62E (E-selectin)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Applications: ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone: CL2
Conjugate: Unconjugated
Gene: SELE
Gene Alias: CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6401
Content And Storage: 4° C
Form: Liquid
Antigen:
CD62E (E-selectin)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with no preservative; pH 7.2-7.4
Gene Accession No.:
P16581
Gene Symbols:
SELE
Immunogen:
Rec. Human CD62E (E-selectin)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
ELISA, Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone:
CL2
Conjugate:
Unconjugated
Gene:
SELE
Gene Alias:
CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6401
Content And Storage:
4° C
Form:
Liquid
Antigen: Caspase 8
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: antibody with no preservative
Gene Accession No.: Q14790
Gene Symbols: Casp8
Immunogen: __
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA
Clone: 4-1-20
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B; apoptosis-related cysteine peptidase; apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 841
Content And Storage: 4° C
Form: Liquid
Antigen:
Caspase 8
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
antibody with no preservative
Gene Accession No.:
Q14790
Gene Symbols:
Casp8
Immunogen:
__
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA
Clone:
4-1-20
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B; apoptosis-related cysteine peptidase; apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
841
Content And Storage:
4° C
Form:
Liquid
Antigen: Podoplanin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: Q86YL7
Gene Symbols: PDPN
Immunogen: Rec. Human Podoplanin
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Applications: Immunohistochemistry
Clone: 4D5aE5E6
Conjugate: Unconjugated
Gene: PDPN
Gene Alias: 29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1a; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; type I cell 40 kDa protein
Host Species: Mouse
Purification Method: Ammonium sulfate precipitation
Regulatory Status: RUO
Gene ID (Entrez): 10630
Content And Storage: 4° C
Form: Liquid
Antigen:
Podoplanin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
Q86YL7
Gene Symbols:
PDPN
Immunogen:
Rec. Human Podoplanin
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Immunohistochemistry
Clone:
4D5aE5E6
Conjugate:
Unconjugated
Gene:
PDPN
Gene Alias:
29kDa cytosolic podoplanin intracellular domain; Aggrus; CTA-520D8.1; E11; E11 antigen epitope; epithelial cell surface transmembrane protein antigen; glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; GP36; Gp38; GP40; HT1A-1; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); Ots8; OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26; PA2.26 antigen; PDPN; PICD; Podoplanin; PSEC0003; PSEC0025; pulmonary type I alveolar epithelial cell transmembrane differentiation marker; RANDAM-2; RP23-348F1.2; RTI140; RTI40; T1a; T1A2; T1A-2; T1alpha; T1-alpha; TI1A; Transmembrane glycoprotein E11; type I cell 40 kDa protein
Host Species:
Mouse
Purification Method:
Ammonium sulfate precipitation
Regulatory Status:
RUO
Gene ID (Entrez):
10630
Content And Storage:
4° C
Form:
Liquid
Antigen: CD62E (E-selectin)
Classification: Monoclonal
Concentration: 10 μL/Test
Formulation: TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Gene Accession No.: P16581
Gene Symbols: SELE
Immunogen: __
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Applications: Flow Cytometry
Clone: CL2
Conjugate: FITC
Gene: SELE
Gene Alias: CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6401
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
CD62E (E-selectin)
Classification:
Monoclonal
Concentration:
10 μL/Test
Formulation:
TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Gene Accession No.:
P16581
Gene Symbols:
SELE
Immunogen:
__
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Flow Cytometry
Clone:
CL2
Conjugate:
FITC
Gene:
SELE
Gene Alias:
CD62 antigen-like family member E; CD62E; e selectin; Elam; ELAM1; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule; endothelial leukocyte adhesion molecule 1; endothelial leukocyte adhesion molecule I; ESEL; E-selectin; LECAM2; leukocyte endothelial cell adhesion molecule 2; leukocyte-endothelial cell adhesion molecule 2; RP1-117P20.2; SELE; selectin E; selectin E (endothelial adhesion molecule 1); selectin, endothelial cell
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
6401
Content And Storage:
4° C, store in dark
Form:
Liquid