Podoplanin Monoclonal Antibody (4D5aE5E6), eBioscience™, Invitrogen™

Description

• Description: BMS1105 specifically recognizes human Podoplanin
• Podoplanin is a 40-kDa type I transmembrane sialomucin-like glycoprotein involved in platelet aggregation and cancer metastasis
• This protein is expressed on lymphatic endothelial cells and follicular dendritic cells, as well as on many human cancers, including squamous cell carcinoma, glioblastoma, seminoma, and mesothelioma
• Podoplanin expression has been demonstrated to be regulated by the Fos protein of the Activating Protein-1 (AP-1) transcription factor complex
• Much of its functionality arises via interaction with its endogenous receptor, C-type lectin-like receptor-2 (CLEC-2)
• Applications Tested: Immunohistochemistry
• Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight
• Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs
• Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells
• As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes
• Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential
• Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue
• Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells
• Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC
• Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm
• Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.