56-918-542

CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), Alexa Fluor™ 700, eBioscience™, Invitrogen™

Manufacturer: Invitrogen

Select a Size

Pack Size SKU Availability Price
Each of 1 56-918-542-Each-of-1 In Stock ₹ 22,587.84

56-918-542 - Each of 1

₹ 22,587.84

In Stock

Quantity

1

Base Price: ₹ 22,587.84

GST (18%): ₹ 4,065.811

Total Price: ₹ 26,653.651

Antigen

CD185 (CXCR5)

Classification

Monoclonal

Concentration

5 μL/Test

Formulation

PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2

Gene Accession No.

P32302

Gene Symbols

CXCR5

Immunogen

N-terminal extracellular domain

Quantity

100 Tests

Primary or Secondary

Primary

Target Species

Human, Non-human Primate, Rhesus Monkey

Product Type

Antibody

Isotype

IgG2b κ

Applications

Flow Cytometry

Clone

MU5UBEE

Conjugate

Alexa Fluor 700

Gene

CXCR5

Gene Alias

Blr1, Blr-1, Burkitt lymphoma receptor 1, burkitt lymphoma receptor 1 homolog, Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5), Burkitt lymphoma receptor 1, GTP-binding protein, C Cmotif chemokine, C X C motif chemokine, CC motif chemokine, CCmotif chemokine, CD185, CD185 antigen, chemochine (C-X-C motif) receptor 5, chemokine (C-X-C motif) receptor 5, CXC, C-X-C chemokine receptor type 5, CXC motif chemokine, C-X-C motif chemokine receptor 5, CXCR5, CXC-R5, CXCR-5, EGK_06966, Fusin, Gpcr6, GPR9, HUMSTR, LESTR, MDR15, MDR-15, Monocyte-derived receptor 15, neurolymphatic receptor, NLR

Host Species

Mouse

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

643, 701792

Content And Storage

4° C, store in dark, DO NOT FREEZE!

Form

Liquid

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Description

  • Description: The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185
  • CD185, which is also known as C-X-C chemokine receptor 5 (CXCR5) and Burkitt lymphoma receptor 1 (BLR1), is a seven transmembrane G protein-coupled receptor originally identified in Burkitt's lymphoma
  • In peripheral blood, CD185 is expressed on B cells, CD4+ T cells (but not Th1 or Th2 cells), as well as on a subpopulation of memory (CD45RO+) T cells
  • Circulating CD185+ T cells are in a resting state and migrate to the lymph nodes due to expression of CCR7 and CD62L
  • In tonsil, CD185 is expressed on nearly all CD4+ cells together with CD45RO and activation markers such as CD69 and ICOS
  • Tonsillar CD185+ cells have been shown to induce antibody production when co-cultured with B cells, thus supporting their role in providing help to B cells
  • Furthermore, this chemokine receptor plays a critical role in lymphocyte trafficking, in particular T cell migration into the B cell follicles of germinal centers in response to CXCL13, making CD185 an established marker of follicular helper T cells
  • Applications Reported: This MU5UBEE antibody has been reported for use in flow cytometric analysis
  • Applications Tested: This MU5UBEE antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells
  • This may be used at 5 μL (0.125 μg) per test
  • CXCR5 (C-X-Chemokine Receptor Type 5, CD185) also known as Burkitt lymphoma receptor 1 (BLR1) belongs to the CXC chemokine receptor family
  • CXCR5 is a G protein-coupled seven transmembrane receptor for chemokine BLC
  • CXCR5 gene is specifically expressed in Burkitt's lymphoma and lymphatic tissues, such as follicles in lymph nodes, as well as in spleen
  • Studies of CXCR5 suggest that it plays an essential role in B cell migration
  • CXCR5 expression has been reported in human blood and salivary gland and in animal lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil
  • ESTs (expressed sequence tags) have been isolated from human brain, germ cell, lung, lymph, and pancreas
  • G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist
  • All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms
  • An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors
  • Research studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs
  • This &quoteturn-off&quote activity in GPCRs have tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates
  • Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which are used in mental health and allergy applications, respectively.

Compare Similar Items

Show Difference

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Invitrogen

56-918-542

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Antigen:
CD185 (CXCR5)

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2

Gene Accession No.:
P32302

Gene Symbols:
CXCR5

Immunogen:
N-terminal extracellular domain

Quantity:
100 Tests

Primary or Secondary:
Primary

Target Species:
Human, Non-human Primate, Rhesus Monkey

Product Type:
Antibody

Isotype:
IgG2b κ

Applications:
Flow Cytometry

Clone:
MU5UBEE

Conjugate:
Alexa Fluor 700

Gene:
CXCR5

Gene Alias:
Blr1, Blr-1, Burkitt lymphoma receptor 1, burkitt lymphoma receptor 1 homolog, Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5), Burkitt lymphoma receptor 1, GTP-binding protein, C Cmotif chemokine, C X C motif chemokine, CC motif chemokine, CCmotif chemokine, CD185, CD185 antigen, chemochine (C-X-C motif) receptor 5, chemokine (C-X-C motif) receptor 5, CXC, C-X-C chemokine receptor type 5, CXC motif chemokine, C-X-C motif chemokine receptor 5, CXCR5, CXC-R5, CXCR-5, EGK_06966, Fusin, Gpcr6, GPR9, HUMSTR, LESTR, MDR15, MDR-15, Monocyte-derived receptor 15, neurolymphatic receptor, NLR

Host Species:
Mouse

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
643, 701792

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

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Antigen:
__

Classification:
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Concentration:
__

Formulation:
__

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
__

Quantity:
10 mg

Primary or Secondary:
__

Target Species:
__

Product Type:
__

Isotype:
__

Applications:
__

Clone:
__

Conjugate:
__

Gene:
__

Gene Alias:
__

Host Species:
__

Purification Method:
__

Regulatory Status:
__

Gene ID (Entrez):
__

Content And Storage:
__

Form:
__

Img

Invitrogen

56-932-642

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Antigen:
CD326 (EpCAM)

Classification:
Monoclonal

Concentration:
5 μL/Test

Formulation:
PBS with 0.2% BSA and 0.09% sodium azide, pH 7.2

Gene Accession No.:
P16422

Gene Symbols:
EPCAM

Immunogen:
__

Quantity:
100 Tests

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG1 κ

Applications:
Flow Cytometry

Clone:
1B7

Conjugate:
Alexa Fluor 700

Gene:
EPCAM

Gene Alias:
adenocarcinoma-associated antigen, CD326, cell surface glycoprotein Trop-1, DIAR5, EGP, EGP-2, EGP314, EGP40, EPCAM, Ep-CAM, EpCAM1, epithelial cell adhesion molecule, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, ESA, GA733-2, gp40, hEGP314, HNPCC8, human epithelial glycoprotein-2, KS 1/4 antigen, KS1/4, KSA, Ly74, lymphocyte antigen 74, M1S2, M4S1, major gastrointestinal tumor-associated protein GA733-2, mEGP314, membrane component, chromosome 4, surface marker (35kD glycoprotein), MIC18, MK-1, panepithelial glycoprotein 314, protein 289A, Protein D5.7A, Tacsd1, Tacstd1, TROP1, Trop-1 protein, Tumor-associated calcium signal transducer 1

Host Species:
Mouse

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
4072

Content And Storage:
4° C, store in dark, DO NOT FREEZE!

Form:
Liquid

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Antigen:
__

Classification:
__

Concentration:
__

Formulation:
__

Gene Accession No.:
__

Gene Symbols:
__

Immunogen:
__

Quantity:
50 mg

Primary or Secondary:
__

Target Species:
__

Product Type:
__

Isotype:
__

Applications:
__

Clone:
__

Conjugate:
__

Gene:
__

Gene Alias:
__

Host Species:
__

Purification Method:
__

Regulatory Status:
__

Gene ID (Entrez):
__

Content And Storage:
__

Form:
__