Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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CD21
1 mg/mL
Immunohistochemistry (Paraffin)
Unconjugated
Mouse
Human
P20023
1380
Recombinant human CR2 (CD21) protein fragment (around aa 44-196) (exact sequence is proprietary)
Primary
Store at 4°C.
140 kDa
CR2/1952
Immunohistochemistry-Paraffin 1-2 ug/ml
Monoclonal
Purified
Adaptive Immunity, Dendritic Cell Markers, Immunology
10mM PBS with No Preservative
C3DRSLEB9, CD21, CD21 antigen, Complement C3d receptor, complement component (3d/Epstein Barr virus) receptor 2, complement receptor type 2, Cr2, EBV receptor, Epstein-Barr virus receptor
CR2
IgG1 κ
Protein A or G purified
Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/ CD21. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation.