CD98, Mouse anti-Human, Clone: HBJ127, Novus Biologicals™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
CD98
Concentration
1 mg/mL
Applications
ELISA, Immunofluorescence, Blocking Assay
Conjugate
Unconjugated
Host Species
Mouse
Research Discipline
Biologically Active Proteins, Cell Biology, Cellular Markers, Immunology, Lipid and Metabolism, Plasma Membrane Markers, Signal Transduction
Formulation
PBS
Gene ID (Entrez)
6520
Immunogen
HBJ127 was obtained from hybridomas generated by the fusion of mouse myeloma cells and spleen cells from mice which had been immunized with T24 hyman bladder cancer cells.
Primary or Secondary
Primary
Content And Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone
HBJ127
Dilution
ELISA, Immunocytochemistry/Immunofluorescence, Block/Neutralize
Classification
Monoclonal
Form
Purified
Regulatory Status
RUO
Target Species
Human
Gene Alias
4F2, 4F2hc, 4T2HC, antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,4F2HC, CD98, CD98 antigen, CD98 heavy chain, CD98HC, heavy chain, Lymphocyte activation antigen 4F2 large subunit, MDU1antigen defined by monoclonal 4F2, heavy chain, monoclonal 44D7, NACAE4F2 cell-surface antigen heavy chain, solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen
Gene Symbols
SLC3A2
Isotype
IgG1 κ
Purification Method
Protein A purified
Test Specificity
HBJ127 binds to the CD98 heavy chain at an epitope consisting of residues AFS (aa 442-444) (Itoh et al, 2007). The antibody has not been shown to cross-react with other species. CD98 is expressed at high levels on monocytes and at very low level on peripheral blood T and B lymphocytes, splenocytes, NK cells and granulocytes. CD98 is a disulfide-linked and glycosylated type II integral membrane protein. This protein has roles in normal and neoplastic cell growth and is required for the function of light chain amino acid transporters. It is also involved in sodium-independent transport of large neitral amino acids and in guiding and targeting LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, CD98 acts as an arginine/glutamine exchanger.
Related Products
Description
- CD98 Monoclonal specifically detects CD98 in Human samples
- It is validated for ELISA, Immunocytochemistry/Immunofluorescence, Block/Neutralize.
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Antigen: CD98
Concentration: 1 mg/mL
Applications: ELISA, Immunofluorescence, Blocking Assay
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Biologically Active Proteins, Cell Biology, Cellular Markers, Immunology, Lipid and Metabolism, Plasma Membrane Markers, Signal Transduction
Formulation: PBS
Gene ID (Entrez): 6520
Immunogen: HBJ127 was obtained from hybridomas generated by the fusion of mouse myeloma cells and spleen cells from mice which had been immunized with T24 hyman bladder cancer cells.
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone: HBJ127
Dilution: ELISA, Immunocytochemistry/Immunofluorescence, Block/Neutralize
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: 4F2, 4F2hc, 4T2HC, antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43,4F2HC, CD98, CD98 antigen, CD98 heavy chain, CD98HC, heavy chain, Lymphocyte activation antigen 4F2 large subunit, MDU1antigen defined by monoclonal 4F2, heavy chain, monoclonal 44D7, NACAE4F2 cell-surface antigen heavy chain, solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen
Gene Symbols: SLC3A2
Isotype: IgG1 κ
Purification Method: Protein A purified
Test Specificity: HBJ127 binds to the CD98 heavy chain at an epitope consisting of residues AFS (aa 442-444) (Itoh et al, 2007). The antibody has not been shown to cross-react with other species. CD98 is expressed at high levels on monocytes and at very low level on peripheral blood T and B lymphocytes, splenocytes, NK cells and granulocytes. CD98 is a disulfide-linked and glycosylated type II integral membrane protein. This protein has roles in normal and neoplastic cell growth and is required for the function of light chain amino acid transporters. It is also involved in sodium-independent transport of large neitral amino acids and in guiding and targeting LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, CD98 acts as an arginine/glutamine exchanger.
Antigen: Fibrinopeptide B
Concentration: 1 mg/mL
Applications: ELISA
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cell Cycle and Replication
Formulation: PBS
Gene ID (Entrez): 2244
Immunogen: 8E5 was prepared fusing Sp2/o myeloma cells with spleen cells derived from female BALB/c mice immunized with a synthetic beta-fibrin peptide seqeunce GHRPLDKC conjugated to MB-KLH (maleimidobenzoylated keyhole limpet hemocyanin).
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone: 800000
Dilution: ELISA, In vivo assay
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: fibrinogen beta chain, fibrinogen, B beta polypeptide, MGC104327, MGC120405
Gene Symbols: FGB
Isotype: IgG1 κ
Purification Method: Protein A purified
Test Specificity: 8E5 binds to the amino-terminal region of the beta-chain of human fibrin at an epitope consiting of GHRPLDKC. Binding is possible in both the monomeric form and the polymeric form of the protein. This peptide sequence is found only in fibrin, and not in its precursor fibrinogen and so there is no cross-reactivity with fibrinogen. Fibrin is a non-globular protein which plays a role in the clotting of blood and circulates as the precursor fibrinogen. Polymerization occurs through the action of the protease thrombin, which results in the active fibrin. Fibrin polymerizes as an insoluble matrix and forms a clot along with platelets over a wound site.
Antigen: Fibrinopeptide B
Concentration: 1 mg/mL
Applications: ELISA
Conjugate: Unconjugated
Host Species: Mouse
Research Discipline: Cell Cycle and Replication
Formulation: PBS
Gene ID (Entrez): 2244
Immunogen: 8E5 was prepared fusing Sp2/o myeloma cells with spleen cells derived from female BALB/c mice immunized with a synthetic beta-fibrin peptide seqeunce GHRPLDKC conjugated to MB-KLH (maleimidobenzoylated keyhole limpet hemocyanin).
Primary or Secondary: Primary
Content And Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clone: 800000
Dilution: ELISA, In vivo assay
Classification: Monoclonal
Form: Purified
Regulatory Status: RUO
Target Species: Human
Gene Alias: fibrinogen beta chain, fibrinogen, B beta polypeptide, MGC104327, MGC120405
Gene Symbols: FGB
Isotype: IgG1 κ
Purification Method: Protein A purified
Test Specificity: 8E5 binds to the amino-terminal region of the beta-chain of human fibrin at an epitope consiting of GHRPLDKC. Binding is possible in both the monomeric form and the polymeric form of the protein. This peptide sequence is found only in fibrin, and not in its precursor fibrinogen and so there is no cross-reactivity with fibrinogen. Fibrin is a non-globular protein which plays a role in the clotting of blood and circulates as the precursor fibrinogen. Polymerization occurs through the action of the protease thrombin, which results in the active fibrin. Fibrin polymerizes as an insoluble matrix and forms a clot along with platelets over a wound site.