7190726
TRPC6 Monoclonal Antibody (3F2.H10.F2), Rockland™
Mouse Monoclonal Antibody
Manufacturer: Fischer Scientific
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Antigen
TRPC6
Concentration
1 mg/mL
Classification
Monoclonal
Form
Liquid
Regulatory Status
RUO
Formulation
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias
AV025995; Calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; FSGS2; HGNC:12338; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; Short transient receptor potential channel 6; transient receptor potential cation channel subfamily C member 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; Trp6; TRP-6; trp6A; TRPC6; Trrp6
Gene Symbols
Trpc6
Isotype
IgG1 κ
Content And Storage
-20°C, Avoid Freeze/Thaw Cycles
Gene
Trpc6
Clone
3F2.H10.F2
Applications
ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate
Unconjugated
Host Species
Mouse
Target Species
Chimpanzee, Human
Gene Accession No.
Q9Y210
Gene ID (Entrez)
451503, 7225
Immunogen
This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human TRPC6 protein.
Primary or Secondary
Primary
Product Type
Antibody
Related Products
Description
- Store vial at -20°C prior to opening
- Aliquot contents and freeze at -20°C or below for extended storage
- Avoid cycles of freezing and thawing
- Centrifuge product if not completely clear after standing at room temperature
- This product is stable for several weeks at 4°C as an undiluted liquid
- Dilute only prior to immediate use
- This antibody is specific for human TRPC6 protein
- A BLAST analysis was used to suggest cross-reactivity with TRPC6 from chimpanzee based on 100% homology with the immunizing sequence
- Cross-reactivity with TRPC6 from other sources has not been determined
- Trpc6 forms a receptor-activated calcium channel in the cell membrane
- The Trpc6 channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system
- Activation of the Trpc6 channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium
- Defects in the Trpc6 gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2)
- Further, Trpc6 is a member of the mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the 'canonical TRP' (TRPC) family
- The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types
- Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors
- When expressed in transfected cells, Trpc6 acts as a non-selective store-independent receptor-activated cation channel
- Trpc6 is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation
- There is increasing evidence that Trpc6 encodes endogenous DAG-activated receptor-operated cation channels in vivo
- Diseases associated with TRPC6 include Glomerulosclerosis, Focal Segmental, 2 and Focal Segmental Glomerulosclerosis.
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Antigen: TRPC6
Concentration: 1 mg/mL
Classification: Monoclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: AV025995; Calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; FSGS2; HGNC:12338; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; Short transient receptor potential channel 6; transient receptor potential cation channel subfamily C member 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; Trp6; TRP-6; trp6A; TRPC6; Trrp6
Gene Symbols: Trpc6
Isotype: IgG1 κ
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: Trpc6
Clone: 3F2.H10.F2
Applications: ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Mouse
Target Species: Chimpanzee, Human
Gene Accession No.: Q9Y210
Gene ID (Entrez): 451503, 7225
Immunogen: This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human TRPC6 protein.
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
TRPC6
Concentration:
1 mg/mL
Classification:
Monoclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
AV025995; Calcium entry channel; FLJ11098; FLJ14863; focal segmental glomerulosclerosis 2; FSGS2; HGNC:12338; LLHWJM002; LLHWJM003; LLHWJM004; mtrp6; Short transient receptor potential channel 6; transient receptor potential cation channel subfamily C member 6; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; Trp6; TRP-6; trp6A; TRPC6; Trrp6
Gene Symbols:
Trpc6
Isotype:
IgG1 κ
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
Trpc6
Clone:
3F2.H10.F2
Applications:
ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Mouse
Target Species:
Chimpanzee, Human
Gene Accession No.:
Q9Y210
Gene ID (Entrez):
451503, 7225
Immunogen:
This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of human TRPC6 protein.
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: ROBO-1
Concentration: 1 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: AW494633; AW742721; Deleted in U twenty twenty; Dutt1; FLJ21882; Gm310; HGNC:10249; H-Robo-1; MGC131599; MGC133277; Robo1; roundabout 1; roundabout guidance receptor 1; Roundabout homolog 1; roundabout homolog 1 (Drosophila); roundabout, axon guidance receptor, homolog 1; roundabout, axon guidance receptor, homolog 1 (Drosophila); SAX3
Gene Symbols: ROBO1
Isotype: __
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: ROBO1
Clone: __
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Canine, Human, Mouse, Rat
Gene Accession No.: O55005, O89026, Q9Y6N7
Gene ID (Entrez): 19876, 487690, 58946, 6091
Immunogen: __
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
ROBO-1
Concentration:
1 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
AW494633; AW742721; Deleted in U twenty twenty; Dutt1; FLJ21882; Gm310; HGNC:10249; H-Robo-1; MGC131599; MGC133277; Robo1; roundabout 1; roundabout guidance receptor 1; Roundabout homolog 1; roundabout homolog 1 (Drosophila); roundabout, axon guidance receptor, homolog 1; roundabout, axon guidance receptor, homolog 1 (Drosophila); SAX3
Gene Symbols:
ROBO1
Isotype:
__
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
ROBO1
Clone:
__
Applications:
ELISA, Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Canine, Human, Mouse, Rat
Gene Accession No.:
O55005, O89026, Q9Y6N7
Gene ID (Entrez):
19876, 487690, 58946, 6091
Immunogen:
__
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: Phospho-SAE1 (Ser185)
Concentration: 1.02 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: 2400010M20Rik; 2610044L12Rik; activator of SUMO1; AL033372; AOS1; AW743391; D7Ertd177e; FLJ3091; HSPC140; SAE1; sentrin/SUMO-activating protein AOS1; SUA1; SUMO-1 activating enzyme E1 N subunit; SUMO1 activating enzyme subunit 1; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; ubiquitin-like (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme; Ubl1a1; Uble1a
Gene Symbols: SAE1
Isotype: __
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: SAE1
Clone: __
Applications: ELISA, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Bovine, Canine, Human, Mouse, Rat
Gene Accession No.: A2VE14, Q6AXQ0, Q9R1T2, Q9UBE0
Gene ID (Entrez): 10055, 308384, 476425, 505512, 56459
Immunogen: __
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
Phospho-SAE1 (Ser185)
Concentration:
1.02 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
2400010M20Rik; 2610044L12Rik; activator of SUMO1; AL033372; AOS1; AW743391; D7Ertd177e; FLJ3091; HSPC140; SAE1; sentrin/SUMO-activating protein AOS1; SUA1; SUMO-1 activating enzyme E1 N subunit; SUMO1 activating enzyme subunit 1; SUMO-1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO-activating enzyme subunit 1, N-terminally processed; ubiquitin-like (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme E1A; ubiquitin-like 1 (sentrin) activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A; ubiquitin-like protein SUMO-1 activating enzyme; Ubl1a1; Uble1a
Gene Symbols:
SAE1
Isotype:
__
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
SAE1
Clone:
__
Applications:
ELISA, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Bovine, Canine, Human, Mouse, Rat
Gene Accession No.:
A2VE14, Q6AXQ0, Q9R1T2, Q9UBE0
Gene ID (Entrez):
10055, 308384, 476425, 505512, 56459
Immunogen:
__
Primary or Secondary:
Primary
Product Type:
Antibody
Antigen: Phospho-RON (Tyr1360)
Concentration: 0.79 mg/mL
Classification: Polyclonal
Form: Liquid
Regulatory Status: RUO
Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias: CD136; CDw136; c-met-related tyrosine kinase; friend virus susceptibility 2; Fv2; Fv-2; macrophage stimulating 1 receptor; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; Mst1r; MST1R variant RON30; MST1R variant RON62; p185-Ron; protein tyrosine kinase 8; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; receptor protein tyrosine kinase, c-met-related; RON; RON variant E2E3; Stem cell-derived tyrosine kinase; Stk
Gene Symbols: MST1R
Isotype: __
Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
Gene: MST1R
Clone: __
Applications: ELISA, Immunoprecipitation, Western Blot
Conjugate: Unconjugated
Host Species: Rabbit
Target Species: Human
Gene Accession No.: Q04912
Gene ID (Entrez): 4486
Immunogen: __
Primary or Secondary: Primary
Product Type: Antibody
Antigen:
Phospho-RON (Tyr1360)
Concentration:
0.79 mg/mL
Classification:
Polyclonal
Form:
Liquid
Regulatory Status:
RUO
Formulation:
0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
Gene Alias:
CD136; CDw136; c-met-related tyrosine kinase; friend virus susceptibility 2; Fv2; Fv-2; macrophage stimulating 1 receptor; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; MSP receptor; Mst1r; MST1R variant RON30; MST1R variant RON62; p185-Ron; protein tyrosine kinase 8; Protein-tyrosine kinase 8; PTK8; PTK8 protein tyrosine kinase 8; receptor protein tyrosine kinase, c-met-related; RON; RON variant E2E3; Stem cell-derived tyrosine kinase; Stk
Gene Symbols:
MST1R
Isotype:
__
Content And Storage:
-20°C, Avoid Freeze/Thaw Cycles
Gene:
MST1R
Clone:
__
Applications:
ELISA, Immunoprecipitation, Western Blot
Conjugate:
Unconjugated
Host Species:
Rabbit
Target Species:
Human
Gene Accession No.:
Q04912
Gene ID (Entrez):
4486
Immunogen:
__
Primary or Secondary:
Primary
Product Type:
Antibody