ABN1665MI
MilliporeSigma™ Aβ-42, oligomeric (VIA), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1665MI-Each-of-1 | In Stock | ₹ 37,453.03 |
ABN1665MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,453.03
GST (18%): ₹ 6,741.545
Total Price: ₹ 44,194.575
Antigen
Aβ-42, oligomeric (VIA)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
APP, A4, AD1
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Neutralization, Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in PBS without preservatives.
Gene Accession No.
P05067
Immunogen
Aggregated synthetic hexapeptide VIAVIA composed of two copies of Aβ-42 C-terminal end 3-amino acid sequence (Bodani, R.U., et al. (2015). ACS Chem. Neurosci. 6(12):1981-1989).
Quantity
100 μg
Research Discipline
Neuroscience
Test Specificity
This polyclonal antiserum (VIA) recognizes a distinct epitope specific to Aβ-42 oligomers. VIA does not recognize classic amyloid plaques composed of fibrillar Aβ or Aβ-40 (Bodani, R.U., et al. (2015). ACS Chem. Neurosci. 6(12):1981-1989).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Related Products
Description
- Amyloid beta A4 protein (UniProt P05067; also known as ABPP, Alzheimer disease amyloid protein, Amyloid precursor protein, APP, APPI, Cerebral vascular amyloid peptide, CVAP, PN-II, PreA4, Protease nexin-II) is encoded by the APP (also known as A4, AD1) gene (Gene ID 351) in human
- Amyloid precursor protein (APP) is initially produced with a signal peptide sequence (a.a
- 1-17), the removal of which yields the mature protein with a large extracellular portion (a.a
- 18-699), followed by a transmembrane segment (a.a
- 700-723) and a cytoplasmic (a.a
- 724-770) tail
- APP can be further processed by the α-, β-, and γ-secretases in two alternative processing pathways
- In the non-amyloidogenic pathway, APP is first cleaved by the plasma membrane-localized α-secretase to generate an N-terminal extracellular sAPPα fragment (a.a
- 18-687) and a membrane-bound C-terminal fragment C83 (CTFα), which can be further cleaved by γ-secretase to produce a non-toxic small peptide p3 and a cytoplasmic APP intracellular domain (AICD)
- In the amyloidogenic pathway, APP undergoes β-cleavage in BACE-1 (β-site APP-cleaving enzyme)-enriched endosomes to generate an N-terminal extracellular sAPPβ fragment (a.a
- 18-671) and a membrane-bound C-terminal fragment C99 (CTFβ)
- Subsequent cleavage of C99 by γ-secretase releases the amyloid β peptides, Aβ1-42 (672-713) and Aβ1-40 (672-711), and AICD
- Aβ accumulation in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer's disease (AD)
- Growing evidences implicate soluble oligomers as the more toxic species and the extent of oligomer formation and assembly correlates better with disease progression and cognitive dysfunction
- These Aβ oligomers are able to induce other aggregation-prone proteins, including α-synuclein (α-syn), prion protein (PrP), and TDP-43, to assume oligomeric conformations
- These proteins can then seed tau aggregation, resulting in neurodegeneration.
Compare Similar Items
Show Difference
Antigen: Aβ-42, oligomeric (VIA)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: APP, A4, AD1
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Neutralization, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in PBS without preservatives.
Gene Accession No.: P05067
Immunogen: Aggregated synthetic hexapeptide VIAVIA composed of two copies of Aβ-42 C-terminal end 3-amino acid sequence (Bodani, R.U., et al. (2015). ACS Chem. Neurosci. 6(12):1981-1989).
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: This polyclonal antiserum (VIA) recognizes a distinct epitope specific to Aβ-42 oligomers. VIA does not recognize classic amyloid plaques composed of fibrillar Aβ or Aβ-40 (Bodani, R.U., et al. (2015). ACS Chem. Neurosci. 6(12):1981-1989).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen:
Aβ-42, oligomeric (VIA)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
APP, A4, AD1
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Neutralization, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in PBS without preservatives.
Gene Accession No.:
P05067
Immunogen:
Aggregated synthetic hexapeptide VIAVIA composed of two copies of Aβ-42 C-terminal end 3-amino acid sequence (Bodani, R.U., et al. (2015). ACS Chem. Neurosci. 6(12):1981-1989).
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
This polyclonal antiserum (VIA) recognizes a distinct epitope specific to Aβ-42 oligomers. VIA does not recognize classic amyloid plaques composed of fibrillar Aβ or Aβ-40 (Bodani, R.U., et al. (2015). ACS Chem. Neurosci. 6(12):1981-1989).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Antigen: __
Classification: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Antigen: HD-polyCys-Ct
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Serum
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: A synthetic peptide corresponding to the C-terminus of the predicted polyCys frame of HD in the CTG direction (alpha-HD-Cys-Ct).
Quantity: 100 μL
Research Discipline: Neuroscience
Test Specificity: This rabbit polyclonal antibody specifically detects RAN proteins with PolyCys.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Antigen:
HD-polyCys-Ct
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Serum
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
A synthetic peptide corresponding to the C-terminus of the predicted polyCys frame of HD in the CTG direction (alpha-HD-Cys-Ct).
Quantity:
100 μL
Research Discipline:
Neuroscience
Test Specificity:
This rabbit polyclonal antibody specifically detects RAN proteins with PolyCys.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Antigen: HD-polyCys-Ct
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Serum
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: A synthetic peptide corresponding to the C-terminus of the predicted polyCys frame of HD in the CTG direction (alpha-HD-Cys-Ct).
Quantity: 25 μL
Research Discipline: Neuroscience
Test Specificity: This rabbit polyclonal antibody specifically detects RAN proteins with PolyCys.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Antigen:
HD-polyCys-Ct
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Serum
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
A synthetic peptide corresponding to the C-terminus of the predicted polyCys frame of HD in the CTG direction (alpha-HD-Cys-Ct).
Quantity:
25 μL
Research Discipline:
Neuroscience
Test Specificity:
This rabbit polyclonal antibody specifically detects RAN proteins with PolyCys.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.