ABN1380MI
MilliporeSigma™ Caspr2, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1380MI-Each-of-1 | In Stock | ₹ 38,734.72 |
ABN1380MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
Caspr2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CNTNAP2, AUTS15, CASPR2, CDFE, KIAA0868
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Specificity of this polyclonal antiserum was confirmed by the lack of target detection when using tissue samples from Capr2 knock-out mice. This polyclonal antiserum targets extracellular region absent from human Caspr2 spliced isoform 2 (Uniprot Q9UHC6-2).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.
Q9UHC6
Immunogen
Human IgG1 Fc-tagged recombinant human Caspr2 extracellular domain fragment.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_054860
Target Species
Mouse
Form
Serum
Related Products
Description
- Contactin-associated protein-like 2 (UniProt Q9UHC6; also known as Cell recognition molecule Caspr2) is encoded by the CNTNAP2 (also known as AUTS15, CASPR2, CDFE, KIAA0868) gene (Gene ID 26047) in human
- Caspr2 is a neurexin superfamily member that functions as a neuronal cell adhesion protein
- Originally identified in myelinating nerves, Caspr2 serves to cluster voltage-gated potassium (Kv) channels at the juxtaparanode, a membrane domain adjacent to the node of Ranvier, where it forms a barrier holding nodal components in place
- Caspr2 is found in axons, dendrites, dendritic spines and the soma of mature pyramidal neurons in the central nervous system (CNS)
- Caspr2 and its partner Contactin 2 are found in the synaptic plasma membranes fraction of the forebrain
- In the absence of Caspr2, new synaptic spines are unable to stabilize, resulting in decreased spine density and altered spine morphology as well as downregulated AMPA receptor subunit on the spines in mice
- CNTNAP2 gene mutations are linked to autism spectrum disorder (ASD) in human
- Likewise, Cntnap2-knockout mice exhibit core autism-like deficits including abnormal social behavior and communication, and behavior inflexibility
- Caspr2 is produced with a signal peptide (a.a
- 1-27), the removal of which yields the mature transmembrane proein with a large extracellular region (a.a
- 28-1262), followed by a transmembrane domain (a.a
- 1263-1283) and a cytoplasmic tail (human a.a
- 1284-1331 and mouse a.a
- 1284-1332)
- The extracellular region contains an N-terminal Discoidin domain (a.k.a
- F5/8 type C domain or C2-like domain; human a.a
- 35-181), four Laminin G-like domains (human a.a
- 216-368, 401-552, 799-963, 1055-1214), two EGF-like domains (human a.a
- 554-591 and 963-1002), and a Fibrinogen C-terminal domain (human a.a
- 592-798).
Compare Similar Items
Show Difference
Antigen: Caspr2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CNTNAP2, AUTS15, CASPR2, CDFE, KIAA0868
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Specificity of this polyclonal antiserum was confirmed by the lack of target detection when using tissue samples from Capr2 knock-out mice. This polyclonal antiserum targets extracellular region absent from human Caspr2 spliced isoform 2 (Uniprot Q9UHC6-2).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: Q9UHC6
Immunogen: Human IgG1 Fc-tagged recombinant human Caspr2 extracellular domain fragment.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_054860
Target Species: Mouse
Form: Serum
Antigen:
Caspr2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CNTNAP2, AUTS15, CASPR2, CDFE, KIAA0868
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Specificity of this polyclonal antiserum was confirmed by the lack of target detection when using tissue samples from Capr2 knock-out mice. This polyclonal antiserum targets extracellular region absent from human Caspr2 spliced isoform 2 (Uniprot Q9UHC6-2).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
Q9UHC6
Immunogen:
Human IgG1 Fc-tagged recombinant human Caspr2 extracellular domain fragment.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_054860
Target Species:
Mouse
Form:
Serum
Antigen: phospho-TrkA (Tyr794)
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Applications: Immunocytochemistry, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P35739
Immunogen: Linear peptide corresponding to rat TrkA sequence near the C-terminus with phosphorylated Tyr794.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_067600
Target Species: Human, Rat
Form: __
Antigen:
phospho-TrkA (Tyr794)
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Applications:
Immunocytochemistry, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P35739
Immunogen:
Linear peptide corresponding to rat TrkA sequence near the C-terminus with phosphorylated Tyr794.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_067600
Target Species:
Human, Rat
Form:
__
Antigen: Beta-glucocerebrosidase (GBA)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: GBA, GC, GLUC
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This mouse polyclonal antiserum detected the expected target band only in lysate from human beta-glucocerebrosidase-/GBA-transfected, but not untransfected, COS-7 cells. This polyclonal antiserum is reactive toward unglycosylated, glycosylated, as well as deglycosylated GBA following PNGase F treatment (Novo, J.B., et al. (2010). Mol. Biotechnol. 46(3):279-286).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Mouse polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: P04062
Immunogen: His-tagged recombinant full-length human mature Beta-glucocerebrosidase (GBA).
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_000148
Target Species: Human
Form: Serum
Antigen:
Beta-glucocerebrosidase (GBA)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
GBA, GC, GLUC
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This mouse polyclonal antiserum detected the expected target band only in lysate from human beta-glucocerebrosidase-/GBA-transfected, but not untransfected, COS-7 cells. This polyclonal antiserum is reactive toward unglycosylated, glycosylated, as well as deglycosylated GBA following PNGase F treatment (Novo, J.B., et al. (2010). Mol. Biotechnol. 46(3):279-286).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Mouse polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
P04062
Immunogen:
His-tagged recombinant full-length human mature Beta-glucocerebrosidase (GBA).
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_000148
Target Species:
Human
Form:
Serum
Antigen: __
Classification: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__