ABN1018MI
MilliporeSigma™ LRP1, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1018MI-Each-of-1 | In Stock | ₹ 38,734.72 |
ABN1018MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
LRP1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
LRP1, A2MR, APR
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Recognizes the Pro- and mature LRP-1 (a.a. 1-4544 and 20-4544, respectively), the beta-secretase-cleaved, membrane-bound LRP-85, and the gamma-secretase-cleaved intracellular domain LRPICD fragment, but not the beta-secretase-cleaved extracellular LRP-515 fragment.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.
Q07954
Immunogen
GST-tagged recombinant human LRP1 intracellular domain (LRPICD).
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_002323
Target Species
Mouse
Form
Serum
Related Products
Description
- Prolow-density lipoprotein receptor-related protein 1 (UniProt Q07954; also known as A2MR, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor, CD91, LRP-1) is encoded by the LRP1 (also known as A2MR, APR) gene (Gene ID 4035) in human
- LRP1 is an LDLR family member expressed by vascular endothelial cells forming the blood-brain barrier (BBB), vascular mural cells (pericytes and vascular smooth muscle cells (VSMCs)), neurons, and astrocytes
- LRP1 recognizes and mediates the endocytosis of more than 40 different ligands, including apolipoprotein E (apoE), APP and Aβ
- LRP1 is the primary receptor mediating transport of Aβ across the BBB into circulation, thereby clearing it from the brain
- LRP1 is synthesized with a signal peptide sequence (a.a
- 1-19), posttranslational cleavage yields a soluble form (sLRP1) and a cell surface-bound form composed of an 515kDa extracellular α-chain (LRP-515) and a 85kDa single-transmembrane (a.a
- 4420-4444) β-chain (LRP-85) that contains the 100-amino intracellular domain (LRPICD; a.a
- 4445-4544)
- BACE-1, ADAM-10, ADAM-12, ADAM-17, MT1-MMP, and t-PA are shown to be involved in the shedding of LRP1 to produce sLRP1.
Compare Similar Items
Show Difference
Antigen: LRP1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: LRP1, A2MR, APR
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes the Pro- and mature LRP-1 (a.a. 1-4544 and 20-4544, respectively), the beta-secretase-cleaved, membrane-bound LRP-85, and the gamma-secretase-cleaved intracellular domain LRPICD fragment, but not the beta-secretase-cleaved extracellular LRP-515 fragment.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: Q07954
Immunogen: GST-tagged recombinant human LRP1 intracellular domain (LRPICD).
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_002323
Target Species: Mouse
Form: Serum
Antigen:
LRP1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
LRP1, A2MR, APR
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes the Pro- and mature LRP-1 (a.a. 1-4544 and 20-4544, respectively), the beta-secretase-cleaved, membrane-bound LRP-85, and the gamma-secretase-cleaved intracellular domain LRPICD fragment, but not the beta-secretase-cleaved extracellular LRP-515 fragment.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
Q07954
Immunogen:
GST-tagged recombinant human LRP1 intracellular domain (LRPICD).
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_002323
Target Species:
Mouse
Form:
Serum
Antigen: Sacsin
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal antibody in PBS with 0.05% sodium azide and 50% glycerol.
Gene Accession No.: Q9NZJ4
Immunogen: KLH-conjugated recombinant protein corresponding to the C-terminus of human Sacsin.
Quantity: 200 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_055178
Target Species: Human, Monkey, Mouse, Rat
Form: __
Antigen:
Sacsin
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal antibody in PBS with 0.05% sodium azide and 50% glycerol.
Gene Accession No.:
Q9NZJ4
Immunogen:
KLH-conjugated recombinant protein corresponding to the C-terminus of human Sacsin.
Quantity:
200 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_055178
Target Species:
Human, Monkey, Mouse, Rat
Form:
__
Antigen: GAD65
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Western Blot
Concentration: __
Formulation: Purified Rabbit Polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to human GAD65.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_000809
Target Species: Canine, Human, Mouse, Porcine, Rat
Form: __
Antigen:
GAD65
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Western Blot
Concentration:
__
Formulation:
Purified Rabbit Polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to human GAD65.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_000809
Target Species:
Canine, Human, Mouse, Porcine, Rat
Form:
__
Antigen: HNF-6
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Applications: Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q9UBC0
Immunogen: KLH-conjugated linear peptide corresponding to human HNF-6 near the C-terminus.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_004489
Target Species: Human
Form: __
Antigen:
HNF-6
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Applications:
Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q9UBC0
Immunogen:
KLH-conjugated linear peptide corresponding to human HNF-6 near the C-terminus.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_004489
Target Species:
Human
Form:
__