ABS1049MI
MilliporeSigma™ Ecm29 (Ab Ecm29-2), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1049MI-Each-of-1 | In Stock | ₹ 37,646.40 |
ABS1049MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,646.40
GST (18%): ₹ 6,776.352
Total Price: ₹ 44,422.752
Antigen
Ecm29 (Ab Ecm29-2)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ECM29, KIAA0368
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antiserum (Ab Ecm29-2) stained 26S proteasome-containing endosomes in HeLa cells and detected the ∽205 kDa target band in HeLa cell lysate and in various mouse tissue homogenates (Gorbea, C., et al., (2004). J. Biol. Chem. 2279(52):54849-54861).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.
Q5VYK3
Immunogen
Ovalbumin-conjugated linear peptide corresponding to a sequence within the HEAT repeats 17 & 18 region of human Ecm29.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
XP_005251907
Target Species
Human
Form
Serum
Related Products
Description
- Proteasome-associated protein ECM29 homolog (UniProt Q5VYK3; also known as Ecm29, Extracellular mutant protein 29 homolog) is encoded by the ECM29 (also known as KIAA0368) gene (Gene ID 23392) in human
- Ecm29 is a large adaptor protein found exclusively on the 26S enzyme to form a subset of 26S proteasomes (Ecm proteasomes), where it functions to link 26S proteasome to molecular motors, centrosome, endoplasmic reticulum, and endocytic vesicles
- Ubiquitinated proteins containing K48- and K63-linked polyubiquitin chains accumulate in the centrosomes during M phase relative to S phase, shRNA-mediated Ecm29 knockdown is found to result in a decreased accumulation of ubiquitinated proteins in the centrosomes
- Ecm29 downregulation is also reported to result in an elevated level of toll-like receptor 3 (TLR3) and enhanced TLR3 signaling as a result of impaired autophagy
- Ecm29 is produced as a 1845-amino acid protein whose initiator methionine is removed posttranslationally to yiled the mature protein (a.a
- 2-1845) composed almost entirely of Huntingtin-elongation factor 3-protein phosphatase 2A-Tor1 (HEAT) repeats, 27 in total (a.a
- 34-1828).
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Antigen: Ecm29 (Ab Ecm29-2)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ECM29, KIAA0368
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antiserum (Ab Ecm29-2) stained 26S proteasome-containing endosomes in HeLa cells and detected the ∽205 kDa target band in HeLa cell lysate and in various mouse tissue homogenates (Gorbea, C., et al., (2004). J. Biol. Chem. 2279(52):54849-54861).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: Q5VYK3
Immunogen: Ovalbumin-conjugated linear peptide corresponding to a sequence within the HEAT repeats 17 & 18 region of human Ecm29.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): XP_005251907
Target Species: Human
Form: Serum
Antigen:
Ecm29 (Ab Ecm29-2)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ECM29, KIAA0368
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antiserum (Ab Ecm29-2) stained 26S proteasome-containing endosomes in HeLa cells and detected the ∽205 kDa target band in HeLa cell lysate and in various mouse tissue homogenates (Gorbea, C., et al., (2004). J. Biol. Chem. 2279(52):54849-54861).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
Q5VYK3
Immunogen:
Ovalbumin-conjugated linear peptide corresponding to a sequence within the HEAT repeats 17 & 18 region of human Ecm29.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
XP_005251907
Target Species:
Human
Form:
Serum
Antigen: IRX-3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Irx3, Irxb1
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with both spliced isoforms of murine IRX-3/IRXB1 reported by UniProt (P81067).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: P81067
Immunogen: Recombinant murine IRX-3/IRXB1 C-terminal fragment.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_001240751
Target Species: Mouse
Form: Serum
Antigen:
IRX-3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Irx3, Irxb1
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with both spliced isoforms of murine IRX-3/IRXB1 reported by UniProt (P81067).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
P81067
Immunogen:
Recombinant murine IRX-3/IRXB1 C-terminal fragment.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001240751
Target Species:
Mouse
Form:
Serum
Antigen: __
Classification: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Antigen: phospho-LRP-6 (Thr1479)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detects LRP6 phosphorylated on Threonine 1479.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Western Blot, Inhibition Assays
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to 10 amino acids surrounding phosphorylated Threonine 1479 of human Low-density lipoprotein receptor-related protein 6 (LRP6).
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_002327
Target Species: Human, Mouse
Form: Purified
Antigen:
phospho-LRP-6 (Thr1479)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detects LRP6 phosphorylated on Threonine 1479.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Western Blot, Inhibition Assays
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to 10 amino acids surrounding phosphorylated Threonine 1479 of human Low-density lipoprotein receptor-related protein 6 (LRP6).
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_002327
Target Species:
Human, Mouse
Form:
Purified