ABS1641MI
MilliporeSigma™ SPTLC2, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1641MI-Each-of-1 | In Stock | ₹ 38,734.72 |
ABS1641MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
SPTLC2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SPTLC2, HSAN1C, KIAA0526, NSAN1C, LCB2
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Target-specificity of this antiserum was verified by negative blotting using pre-immune serum and by target band blocking using immunogen peptides (Hornemann, T., et al. (2006). J. Biol. Chem. 281(49):37275-37281).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.
O15270
Immunogen
A mixture of two linear peptides corresponding to sequences from the N-terminal region and the C-terminal end of human SPTLC2.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_004854
Target Species
Human
Form
Serum
Related Products
Description
- Serine palmitoyltransferase 2 (EC 2.3.1.50; UniProt O15270; also known as hLCB2a, LCB 2, LCB2a, Long chain base biosynthesis protein 2, Long chain base biosynthesis protein 2a, Serine-palmitoyl-CoA transferase 2, SPT 2) is encoded by the SPTLC2 (also known as HSAN1C, KIAA0526, NSAN1C, LCB2) gene (Gene ID 9517) in human
- Serine palmitoyltransferase (SPT) is a pyridoxal 5&prime-phosphate (PLP)-dependent enzyme that catalyses the first step of de novo sphingolipids (SLs) biosynthesis, namely the condensation of L-serine with palmitoyl coenzyme-A to generate 3-ketodehydrosphinganine (KDS) that forms the sphingoid base backbone of all SLs
- The core human SPT homoenzyme is a membrane-bound heterodimer composed of an hLCB1 (SPTLC1) subunit together with either an hLCB2a (SPTLC2) or an hLCB2b (SPTLC3) subunit
- The hLCB1/hLCB2 heterodimer contains a single active site composed of residues from both subunits
- hLCB2a and hLCB2b share 68% sequence identity, with hLCB2b being the isotype that is predominantly expressed in the placenta and prefers shorter chain acyl-CoAs (C12 and C14) to generate short-chain SLs
- In addition, two human small subunits (ssSPTa and ssSPTb) have been identified and found to maximize the catalytic activity and to confer the acyl-CoA substrate chain-length specificity of the hLCB1/hLCB2 core enzyme
- Mutations in hLCB1 and hLCB2a are found in patients with hereditary sensory and autonomic neuropathy type I (HSAN1), an inherited disorder that affects sensory and autonomic neurons due to neurotoxic deoxysphingolipids formation as a result of substrate promiscuity of the mutated SPT enzyme.
Compare Similar Items
Show Difference
Antigen: SPTLC2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SPTLC2, HSAN1C, KIAA0526, NSAN1C, LCB2
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Target-specificity of this antiserum was verified by negative blotting using pre-immune serum and by target band blocking using immunogen peptides (Hornemann, T., et al. (2006). J. Biol. Chem. 281(49):37275-37281).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: O15270
Immunogen: A mixture of two linear peptides corresponding to sequences from the N-terminal region and the C-terminal end of human SPTLC2.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_004854
Target Species: Human
Form: Serum
Antigen:
SPTLC2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SPTLC2, HSAN1C, KIAA0526, NSAN1C, LCB2
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Target-specificity of this antiserum was verified by negative blotting using pre-immune serum and by target band blocking using immunogen peptides (Hornemann, T., et al. (2006). J. Biol. Chem. 281(49):37275-37281).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
O15270
Immunogen:
A mixture of two linear peptides corresponding to sequences from the N-terminal region and the C-terminal end of human SPTLC2.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_004854
Target Species:
Human
Form:
Serum
Antigen: SPTLC1
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: __
Formulation: Rabbit polyclonal antibody serum with 0.05% sodium azide.
Gene Accession No.: O15269
Immunogen: Two linear peptides corresponding to sequences from the N- and a C-terminal regions of human SPTLC1 cytoplasmic domain.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_006406
Target Species: Human
Form: Serum
Antigen:
SPTLC1
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
__
Formulation:
Rabbit polyclonal antibody serum with 0.05% sodium azide.
Gene Accession No.:
O15269
Immunogen:
Two linear peptides corresponding to sequences from the N- and a C-terminal regions of human SPTLC1 cytoplasmic domain.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_006406
Target Species:
Human
Form:
Serum
Antigen: DsbA-L
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects DsbA-L (Glutathione S-transferase kappa 1) in human and mouse cells.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide with 20% glycerol.
Gene Accession No.: __
Immunogen: Myc-tagged full length recombinant protein from mouse.
Quantity: 25 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human, Mouse
Form: __
Antigen:
DsbA-L
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects DsbA-L (Glutathione S-transferase kappa 1) in human and mouse cells.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide with 20% glycerol.
Gene Accession No.:
__
Immunogen:
Myc-tagged full length recombinant protein from mouse.
Quantity:
25 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human, Mouse
Form:
__
Antigen: GSTA4
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This antiserum selectively reacts with Yk from purified rat liver GST K and rat kidney GST J. No reactivity toward Ya, Yc, Yb1, Yb2, Yb3, Yf, or Yn subunits from other forms of purified rat GSTs (Hayes, J.D,, and Mantle, T.J. (1986). Biochem. J. 233(3):779-788).
Content And Storage: −20°C for one year
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: __
Formulation: Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Accession No.: P14942
Immunogen: Purified rat liver GST K (YkYk).
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_001100310
Target Species: Mouse, Rat
Form: Serum
Antigen:
GSTA4
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This antiserum selectively reacts with Yk from purified rat liver GST K and rat kidney GST J. No reactivity toward Ya, Yc, Yb1, Yb2, Yb3, Yf, or Yn subunits from other forms of purified rat GSTs (Hayes, J.D,, and Mantle, T.J. (1986). Biochem. J. 233(3):779-788).
Content And Storage:
−20°C for one year
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
__
Formulation:
Rabbit polyclonal antibody in serum with 0.05% sodium azide.
Gene Accession No.:
P14942
Immunogen:
Purified rat liver GST K (YkYk).
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001100310
Target Species:
Mouse, Rat
Form:
Serum