ABE1977MI
MilliporeSigma™ Cep152 (P7), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABE1977MI-Each-of-1 | In Stock | ₹ 36,534.12 |
ABE1977MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,534.12
GST (18%): ₹ 6,576.142
Total Price: ₹ 43,110.262
Antigen
Cep152 (P7)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CEP152, KIAA0912, MCPH9, SCKL5
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody immunostains centrisomes by indirect fluorescence and detected shRNA-mediated Cep152 knockdown by Western blotting. Target C-terminal region is present in human Cep152 spliced isoforms 3 and 4, but more than 95% absent in spliced isoforms 1 and 2 reported by UniProt (O94986).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 80mM Tris (pH 8.0), 40mM glycine, and 50% ethylene glycol with 0.05% Sodium Azide.
Gene Accession No.
O94986
Immunogen
Recombinant human Cep152 C-terminal fragment.
Quantity
100 μL
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_001181927
Target Species
Human
Related Products
Description
- Centrosomal protein of 152kDa (UniProt O94986; also known as Cep152) is encoded by the CEP152 (also known as KIAA0912, MCPH9, SCKL5) gene (Gene ID 22995) in human
- The mammalian Asl (Asterless) ortholog Cep152 is a centrosomal protein (CEP) that plays an important role in centriole duplication and centriole-to-centrosome conversion
- The centrosome is the main microtubule-organizing center essential spindle formation and chromosome segregation during mitosis
- Centrosomes are composed of two orthogonally arranged centrioles surrounded by pericentriolar material (PCM)
- Centriole duplication begins by assembling a procentriole in G1/S phase, where centrosomal scaffolds Cep152 and Cep192 (Spd-2 ortholog) mediate the recruitment of polo kinase Plk4 to to centrosomes, a key event that triggers the entire duplication process
- New centrioles assemble perpendicularly to pre-existing ones in G1/S and elongate throughout S and G2
- The conversion of fully elongated daughter centrioles into centrosomes during mitotic progression requires sequential loading of Cep135, Cep295 (Ana1 analog) and Cep152 onto daughter centrioles.Cep152 is also an important regulator of genomic integrity and cellular response to DNA damage
- CEP152 gene mutations are identified among individuals with Seckel syndrome, a heterogeneous autosomal recessive disorder characterized by a proportionate short stature, severe microcephaly and mental retardation, and a typical &primebird-head′ facial appearance
- Cep152 impairment in Seckel patients-derived cells leads to accumulation of genomic defects as a reuslt of replicative stress through enhanced activation of ATM signaling and increased H2AX phosphorylation.
Compare Similar Items
Show Difference
Antigen: Cep152 (P7)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: CEP152, KIAA0912, MCPH9, SCKL5
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody immunostains centrisomes by indirect fluorescence and detected shRNA-mediated Cep152 knockdown by Western blotting. Target C-terminal region is present in human Cep152 spliced isoforms 3 and 4, but more than 95% absent in spliced isoforms 1 and 2 reported by UniProt (O94986).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 80mM Tris (pH 8.0), 40mM glycine, and 50% ethylene glycol with 0.05% Sodium Azide.
Gene Accession No.: O94986
Immunogen: Recombinant human Cep152 C-terminal fragment.
Quantity: 100 μL
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_001181927
Target Species: Human
Antigen:
Cep152 (P7)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
CEP152, KIAA0912, MCPH9, SCKL5
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody immunostains centrisomes by indirect fluorescence and detected shRNA-mediated Cep152 knockdown by Western blotting. Target C-terminal region is present in human Cep152 spliced isoforms 3 and 4, but more than 95% absent in spliced isoforms 1 and 2 reported by UniProt (O94986).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 80mM Tris (pH 8.0), 40mM glycine, and 50% ethylene glycol with 0.05% Sodium Azide.
Gene Accession No.:
O94986
Immunogen:
Recombinant human Cep152 C-terminal fragment.
Quantity:
100 μL
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_001181927
Target Species:
Human
Antigen: Sirt5
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Immunohistochemistry, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to human Sirt5.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_036373
Target Species: Chimpanzee, Human, Rat, Rhesus Monkey
Antigen:
Sirt5
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Immunohistochemistry, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to human Sirt5.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_036373
Target Species:
Chimpanzee, Human, Rat, Rhesus Monkey
Antigen: JARID1D
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to human JARID1D.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_004644.2
Target Species: Human, Mouse
Antigen:
JARID1D
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to human JARID1D.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_004644.2
Target Species:
Human, Mouse
Antigen: Ash1L
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to human Ash1L.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_060959
Target Species: Human
Antigen:
Ash1L
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to human Ash1L.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_060959
Target Species:
Human