NF-ATc2 Mouse, Unlabeled, Clone: 4G6-G5, BD

Description

• Description The NF-AT family of transcription factors are regulators of early immune response genes in T cells following their activation by CD40L, FasL and interleukins including IL-2, -3, -4 and -5
• NF-AT proteins function in both signal transduction and transcription control
• The DNA binding, active NF-AT complex contains a cytoplasmic, Ca 2 + /calcineurin dependent, cyclosporin sensitive subunit, designated NF-ATc, which is present in the cytoplasm of resting cells
• Upon cell activation, NF-ATc is dephosphorylated and thus activated by calcineurin, resulting in rapid translocation of NF-ATc to the nucleus
• The active NF-AT complex also contains a nuclear component, designated NF-ATn
• In vitro, NF-AT cooperates with the mitogenic transcription factor AP-1 to induce multiple cytokine genes
• NF-ATc is encoded by four genes: NF-ATc1 (originally named NF-ATc), NF-ATc2 (originally named NF-ATp), NF-ATc3 (NF-AT3), and NF-ATc4 (NF-AT4)
• These proteins are differentially expressed in tissues, suggesting that each may activate distinct sets of genes
• NF-ATc2 is constutively expressed in resting immune cells
• NF-ATc2 is required for the development of Th2 responses and plays a role in the production of IL-4
• Host Species: Mouse Clone: 4G6-G5 Isotype: IgG2a Cross Reactivity: Human, Mouse Western Blotting