ERK (pan ERK) Mouse, Unlabeled, Clone: 16, BD

Description

• The family of serine/threonine kinases known as ERKs (extracellular signal regulated kinases) or MAPKs (mitogen-activated protein kinases) are activated after cell stimulation by a variety of hormones and growth factors
• Cell stimulation induces a signaling cascade that leads to phosphorylation of MEK (MAPK/ERK kinase) which, in turn, activates ERK via tyrosine and threonine phosphorylation
• A myriad of proteins represent the downstream effectors for the active ERK and implicate it in the control of cell proliferation and differentiation, as well as regulation of the cytoskeleton
• Activation of ERK is normally transient and cells possess dual specificity phosphatases that are responsible for its down-regulation
• Furthermore, multiple studies have shown that elevated ERK activity is associated with some cancers
• ERK1 may be observable migrating at 44kDa and ERK2 at 42kDa in addition to a 54kDa ERK and a MAP kinase in the 90kDa range
• Host Species: Mouse Clone: 16 Isotype: IgG2a Species Reactivity: Mouse Immunogen: Rat ERK2 aa
• 219-358 Formula Weight [Chemical]: 42-85kDa Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting