LAP2 Mouse, Unlabeled, Clone: 27, BD

Description

• A specialized extension of the ER, the nuclear envelope (NE) forms the nuclear compartment boundary in eukaryotic cells
• It contains numerous pore complexes and the nucleoplasmic side is linked to nuclear lamina
• The nuclear lamina composes the structural framework for the NE and serves as a chromatin anchor site, thus, playing a major role in interphase nuclear organization
• Many proteins are associated with lamina, particularly the LAPs (Lamina-Associated Polypeptides)
• LAP2 (also known as LAP2 β; ) is a hydrophilic protein with a single transmembrane segment near the C-terminus
• Thus, it has been defined as a type II integral membrane protein with the majority of its structure exposed to the nucleoplasm
• LAP2 binding to lamins contributes to the attachment of the nuclear lamina to the inner nuclear membrane
• LAP2 also binds to chromatin, implying its role in chromosomal organization during mitosis
• Mitotic phosphorylation of LAP2 regulates its binding to lamins and chromosomes during the disassembly and reassembly of mitosis
• Thus, LAP2 is a nuclear protein that plays a role in the organization of the NE during cell cycle progression.