LR11 [SorLA; gp250; Lipoprotein Receptor-11] Mouse, Unlabeled, Clone: 48, BD

Description

• The low-density lipoprotein receptor (LDLR) functions in lipoprotein transport pathways, and is involved in familial hypercholesterolemia
• Homologues of the LDLR may have diverse functions and their ligands may include biological inactive plasma carrier complexes, plasma lipoproteins, yolk precursors, toxins, and extracellular lipoproteins
• LR11 (also known as sorLA-1 and gp250) is a lipoprotein receptor homologue that contains 11 LDL receptor ligand binding repeats (LDLRs), 5 LDL receptor “YWTD”repeats, a large fibronectin-type III (FIII) hexarepeat domain similar to neural adhesion proteins, and a domain with similarity to the yeast receptor for vacuolar protein sorting (Vsp10p)
• LR11mRNA is expressed at high levels in brain, but is also found in liver, pancreas, adrenal gland, and testis
• LR11 can bind the ER and Golgi localized receptor associated protein (RAP), which binds to many members of the LDLR family and prevents aggregation of ligands to the LDLRs
• In addition, LR11 binds apolipoprotein E-containing lipoproteins
• Thus, LR11 is a lipoprotein binding receptor that may have additional functions related to protein sorting and neuronal development
• Immunofluorescence, Immunohistochemistry, Western Blotting