HLA-DR, DP, DQ Mouse anti-Human, BUV395, Clone: Tu39 (also known as Tü39), BD Optibuild™

Description

• The TU39 monoclonal antibody specifically recognizes human major histocompatibility (MHC) Class II HLA-DR, DP and most DQ antigens
• These antigens are encoded by genes within the Human Leukocyte Antigen (HLA) Complex located on chromosome 6
• MHC Class II antigens are transmembrane heterodimeric glycoproteins composed of α chain (36 kDa) and β chain (27 kDa) subunits
• They are expressed primarily on antigen presenting cells which include dendritic cells, monocytes, macrophages, thymic epitheli al cells, and B cells
• They are also expressed on activated T cells
• This molecule plays a major role in mediating cellular interactions during antigen presentation to CD4+ T lineage cells
• The TU39 antibody is reportedly useful for immunophenotyping as well as functional studies including the inhibition of mixed lymphocyte reactions and antibody-mediated complement fixation on target cells
• The antibody was conjugated to BD Horizon™ BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes
• This dye has been exclusively developed by BD Biosciences to have minimal spillover into other detectors, making it an optimal choice for multicolor flow cytometry
• With an Ex Max at 348nm and an Em Max at 395nm, BD Horizon BUV395 can be excited with a 355nm laser and detected with a 379/28 filter.