BDB742696

TWEAK Receptor (CD266) Mouse, BUV395, Clone: ITEM-4, BD Optibuild™

Manufacturer: BD Biosciences

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Pack Size SKU Availability Price
Each of 1 BDB742696-Each-of-1 In Stock ₹ 47,614.14

BDB742696 - Each of 1

₹ 47,614.14

In Stock

Quantity

1

Base Price: ₹ 47,614.14

GST (18%): ₹ 8,570.545

Total Price: ₹ 56,184.685

Antigen

TWEAK Receptor (CD266)

Clone

ITEM-4

Conjugate

Brilliant Ultraviolet 395

Gene Alias

TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14

Immunogen

Human Fn14 transfected P815

Quantity

50 μg

Primary or Secondary

Primary

Content And Storage

Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification

Monoclonal

Concentration

0.2mg/mL

Formulation

Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species

Mouse

Purification Method

Affinity Purified

Regulatory Status

RUO

Target Species

Human

Isotype

IgG2b κ

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Description

  • The ITEM-4 monoclonal antibody specifically binds to the TWEAK Receptor (TWEAK-R/TWEAKR), which is also known as CD266, or Fibroblast growth factor inducible 14 (FGF-inducible 14, FN14)
  • The TWEAK Receptor is a ñ14 kDa type I transmembrane protein that is the 12A family member of the tumor necrosis factor receptor superfamily (TNFRSF12A)
  • It is expressed at low levels in a variety of tissues including, heart, placenta, lung, muscle, and pancreas
  • TWEAK Receptors are relatively highly expressed on HUVEC cells and certain tumor cell lines
  • TWEAK-induced TWEAK Receptor-mediated signaling can play roles in inflammation, the induction of apoptosis in certain cell types, the proliferation and migration of endothelial cells, and can promote angiogenesis within healthy and diseased tissues, eg, tumors
  • The ITEM-4 antibody can induce the death of certain TWEAK-sensitive tumor target cell lines
  • The TWEAK Receptor binds TWEAK (CD255) and can signal intracellularly by interactions with TRAF1, 2, and 3 cytoplasmic proteins leading toNF-κBactivation
  • The ITEM-4 antibody reportedly crossreacts strongly with mouse CD266 as demonstrated by flow cytometric analysis and functional assays
  • The antibody was conjugated to BD Horizon™ BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes
  • This dye has been exclusively developed by BD Biosciences to have minimal spillover into other detectors, making it an optimal choice for multicolor flow cytometry
  • With an Ex Max at 348 nm and an Em Max at 395 nm, BD Horizon BUV395 can be excited with a 355 nm laser and detected with a 379/28 filter
  • BUV395 is a UV-excitable dye that has been developed exclusively by BD Biosciences
  • With an excitation max of 348 nm and emission max of 395 nm, BUV395 can be excited by the 355nm laser and detected in a 379/28 filter
  • This dye is optimal for multicolor flow cytometry because it has little to no spillover into other detectors.

Compare Similar Items

Show Difference

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BD Biosciences

BDB742696

--


Antigen:
TWEAK Receptor (CD266)

Clone:
ITEM-4

Conjugate:
Brilliant Ultraviolet 395

Gene Alias:
TWEAKR, TWEAK-R, TWEAK Receptor, TNFRSF12A, FGF-inducible 14, FN14

Immunogen:
Human Fn14 transfected P815

Quantity:
50 μg

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification:
Monoclonal

Concentration:
0.2mg/mL

Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human

Isotype:
IgG2b κ

Img

BD Biosciences

BDB742697

--


Antigen:
ASGPR 1

Clone:
8D7

Conjugate:
Brilliant Violet 421

Gene Alias:
Asialoglycoprotein receptor 1, ASGR1, ASGP-R1, ASGPR 1, HL-1, CLEC4H1

Immunogen:
Rat Liver membrane constituents

Quantity:
50 μg

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification:
Monoclonal

Concentration:
0.2mg/mL

Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human

Isotype:
IgG1 κ

Img

BD Biosciences

BDB742698

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Antigen:
ASGPR 1

Clone:
8D7

Conjugate:
Brilliant Violet 510

Gene Alias:
Asialoglycoprotein receptor 1, ASGR1, ASGP-R1, ASGPR 1, HL-1, CLEC4H1

Immunogen:
Rat Liver membrane constituents

Quantity:
50 μg

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification:
Monoclonal

Concentration:
0.2mg/mL

Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human

Isotype:
IgG1 κ

Img

BD Biosciences

BDB742699

--


Antigen:
ASGPR 1

Clone:
8D7

Conjugate:
Brilliant Violet 605

Gene Alias:
Asialoglycoprotein receptor 1, ASGR1, ASGP-R1, ASGPR 1, HL-1, CLEC4H1

Immunogen:
Rat Liver membrane constituents

Quantity:
50 μg

Primary or Secondary:
Primary

Content And Storage:
Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

Classification:
Monoclonal

Concentration:
0.2mg/mL

Formulation:
Aqueous buffered solution containing ≤0.09% sodium azide.

Host Species:
Mouse

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Target Species:
Human

Isotype:
IgG1 κ