CD268 (BAFF Receptor) Mouse anti-Human, Brilliant Violet 510, Clone: 11C1, BD Optibuild™

Description

• The 11C1 monoclonal antibody recognizes CD268 which is also known as the B cell activating factor receptor (BAFF-R)
• CD268 is a type III transmembrane protein of approximately 184 residues
• BAFF-R is one of the receptors for B-cell activating factor (BAFF), a member of the TNF family of proteins
• BAFF is a key regulator for B cell differentiation and critical in regulating survival and activation of peripheral B cell populations
• Experiments in the mouse model show that interaction of BAFF with BAFF-R promotes NF-κB activity
• Overexpression of BAFF results in an expanded B cell compartment and autoimmunity in mice
• Mice injected with BAFF-neutralizing-Fc (BAFF-R-Fc) protein showed reduced NF-κB activation, blocking BAFF-induced B cell proliferation
• Reports suggest that the BAFF-BAFF-R interaction may lead to a better understanding of autoimmune disorders
• The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes
• With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set
• BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser
• BV510 is a polymer-based dye that is brighter than BD Horizon V500
• Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.