ErbB3 (HER-3) Mouse, anti-Human, R718, Clone: SGP1, BD OptiBuild™

Description

• The SGP1 monoclonal antibody specifically recognizes human ErbB3 (also known as HER-3), a 160-kDa glycoprotein that is a member of the epidermal growth factor receptor or ErbB family of receptor tyrosine kinases
• Other members of the family include the epidermal growth factor receptor (EGFR, ErbB-1, HER1), ErbB-2 (Neu, HER2), and ErbB-4 (HER4)
• Members of this receptor family mediate the proliferation and differentiation of normal cells
• They have a common structure consisting of an extracellular ligand-binding domain, a transmembrane region, and a cytoplasmic region that has sequence homology to tyrosine kinases, which is inactive in ErbB3
• ErbB3 is expressed on neurons and in tissues from the digestive, urinary and respiratory tracts, the circulatory system, and female and male reproductive organs
• It is overexpressed in a variety of tumors and is undetectable in hematopoietic tissue and cell lines derived from hematopoietic tumors
• ErbB3 is able to form heterodimers with other ErbB family members that have active tyrosine kinases
• This interaction is able to mediate signal transduction upon binding of ErbB3 to its ligand neuregulin, a cell adhesion molecule that is involved in development of the heart and nervous system.