Neuropilin-1 Mouse, anti-Human, R718, Clone: U21-1283, BD OptiBuild™

Description

• The U21-1283 monoclonal antibody specifically recognizes Neuropilin-1 (NRP1), also known as CD304, Blood dendritic cell antigen 4 (BDCA4), and Vascular endothelial cell growth factor 165 receptor (VEGF165R)
• CD304 is a type I transmembrane glycoprotein involved in the development of the nervous and cardiovascular systems
• It mediates the interaction, growth, survival, and migration of a variety of normal and tumor cells
• CD304 is expressed on neurons, thymocytes, regulatory T cells, a subset of T follicular helper cells, dendritic cells, endothelial cells, and certain tumor cells
• Neuropilin-1 has a very short cytoplasmic domain and interacts with various coreceptors to form ligand-binding, signal-transducing receptor complexes
• CD304 complexes with Plexin-A family members to bind chemorepellent Class 3 Semaphorins and guide neuronal axon growth
• It also functions as a coreceptor with VEGFR2/CD309 to stimulate angiogenesis in response to VEGF165
• CD304 mediates the interactions between some T cells and dendritic cells.