FEMA549767

Phospho-Tau (Thr231) Recombinant Rabbit Monoclonal Antibody (1G9), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 FEMA549767-Each-of-1 In Stock ₹ 35,764.08

FEMA549767 - Each of 1

₹ 35,764.08

In Stock

Quantity

1

Base Price: ₹ 35,764.08

GST (18%): ₹ 6,437.534

Total Price: ₹ 42,201.614

Antigen

Phospho-Tau (Thr231)

Classification

Recombinant Monoclonal

Concentration

0.4 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.

P10636

Gene Symbols

MAPT

Immunogen

A synthesized peptide derived from human Phospho-MAPT (T231)

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human

Form

Liquid

Applications

ELISA, Western Blot

Clone

1G9

Conjugate

Unconjugated

Gene

MAPT

Gene Alias

AI413597, AW045860, DDPAC, FLJ31424, FTDP17, FTDP-17, G protein beta1/gamma2 subunit-interacting factor 1, map tau, Mapt, MAPTL, MGC138549, microtubule associated protein tau, microtubule-associated protein tau, microtubule-associated protein tau, isoform 4, microtubules, MSTD, Mtapt, MTBT1, MTBT2, Neurofibrillary tangle protein, neurofibrillary tangles, Neuronal Marker, paired helical filament-tau, PHFtau, PHF-tau, PPND, PPP1R103, protein phosphatase 1, regulatory subunit 103, pTau, RNPTAU, Tau, Tau microtubule-associated protein, tau protein, Tau-4, Tau5, Unknown (protein for MGC:134287)

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

4137

Content And Storage

-20°C or -80°C if preferred

Isotype

IgG

Related Products

Img

Thermo Scientific

FEMA550105

--

Img

Thermo Scientific

FEMA550104

--

Img

Thermo Scientific

FEMA549974

--

Img

Thermo Scientific

ENMN1050

--

Img

Thermo Scientific

ENMN1010

--

Img

Thermo Scientific

ENMN1020B

--

Img

Thermo Scientific

ENMN1020

--

Img

Thermo Scientific

ENMN1010B

--

Description

  • Tau is a neuronal microtubule-associated protein found predominantly on axons
  • The function of Tau is to promote tubulin polymerization and stabilize microtubules
  • The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both
  • Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome
  • The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization
  • In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain
  • Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, μgtimately leading to the degeneration of the affected neurons
  • Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II
  • Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Compare Similar Items

Show Difference

Img

Thermo Scientific

FEMA549767

--


Antigen:
Phospho-Tau (Thr231)

Classification:
Recombinant Monoclonal

Concentration:
0.4 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
P10636

Gene Symbols:
MAPT

Immunogen:
A synthesized peptide derived from human Phospho-MAPT (T231)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Western Blot

Clone:
1G9

Conjugate:
Unconjugated

Gene:
MAPT

Gene Alias:
AI413597, AW045860, DDPAC, FLJ31424, FTDP17, FTDP-17, G protein beta1/gamma2 subunit-interacting factor 1, map tau, Mapt, MAPTL, MGC138549, microtubule associated protein tau, microtubule-associated protein tau, microtubule-associated protein tau, isoform 4, microtubules, MSTD, Mtapt, MTBT1, MTBT2, Neurofibrillary tangle protein, neurofibrillary tangles, Neuronal Marker, paired helical filament-tau, PHFtau, PHF-tau, PPND, PPP1R103, protein phosphatase 1, regulatory subunit 103, pTau, RNPTAU, Tau, Tau microtubule-associated protein, tau protein, Tau-4, Tau5, Unknown (protein for MGC:134287)

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
4137

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG

Img

Thermo Scientific

FEMA549768

--


Antigen:
Phospho-MSK1 (Ser376)

Classification:
Recombinant Monoclonal

Concentration:
0.36 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
O75582

Gene Symbols:
Rps6ka5

Immunogen:
A synthesized peptide derived from human Phospho-RPS6KA5 (S376)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Immunohistochemistry (Paraffin)

Clone:
2F3

Conjugate:
Unconjugated

Gene:
Rps6ka5

Gene Alias:
3110005L17Rik, 6330404E13Rik, 90 kDa ribosomal protein S6 kinase 5, AI854034, kinase MSK1, KS6A5, mitogen and stress-activated protein kinase 1, Msk1, MSPK1, Nuclear mitogen- and stress-activated protein kinase 1, ribosomal protein S6 kinase A5, ribosomal protein S6 kinase alpha-5, ribosomal protein S6 kinase, 90kDa, polypeptide 5, ribosomal protein S6 kinase, polypeptide 5, RLPK, RLSK, Rps6ka5, RSKL, RSK-like protein kinase, S6K-alpha-5

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
9252

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG

Img

Thermo Scientific

FEMA549769

--


Antigen:
Phospho-RPA2 (Thr21)

Classification:
Recombinant Monoclonal

Concentration:
0.32 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
P15927

Gene Symbols:
Rpa2

Immunogen:
A synthesized peptide derived from human Phospho-RPA2 (T21)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Immunocytochemistry

Clone:
3B2

Conjugate:
Unconjugated

Gene:
Rpa2

Gene Alias:
30-kDa protein, AA409079, AI325195, AU020965, HSSB, hypothetical protein, I79_004200, p32, p32-subunit of replication protein A, p34, REPA2, Replication factor A protein 2, replication protein A 32 kDa subunit, Replication protein A 32kDa subunit, Replication protein A 34 kDa subunit, Replication protein A 34kDa subunit, replication protein A2, replication protein A2, 32kDa, replication protein A4, RFA, RF-A protein 2, Rf-A2, RP21C, RP4-547C9.3, RP-A p32, RP-A p34, RPA2, RPA32, RPA34, RPA4, RpLP1, RpP2

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
6118

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG

Img

Thermo Scientific

FEMA549770

--


Antigen:
Phospho-JAK2 (Tyr1007, Tyr1008)

Classification:
Recombinant Monoclonal

Concentration:
0.25 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4

Gene Accession No.:
O60674

Gene Symbols:
JAK2

Immunogen:
A synthesized peptide derived from human Phospho-JAK2 (Y1007 + Y1008)

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human

Form:
Liquid

Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
1A4

Conjugate:
Unconjugated

Gene:
JAK2

Gene Alias:
EC 2.7.10.2, Fd17, JAK 2, JAK2, JAK-2, Janus kinase 2, Janus kinase 2 (a protein tyrosine kinase), JTK 10, JTK10, kinase Jak2, THCYT3, Tyrosine-protein kinase JAK2

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3717

Content And Storage:
-20°C or -80°C if preferred

Isotype:
IgG