MAB3806CMI
MilliporeSigma™ phospho-ATM (Ser1981), Mouse, Unlabeled, Clone: 10H11.E12,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MAB3806CMI-Each-of-1 | In Stock | ₹ 38,734.72 |
MAB3806CMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
phospho-ATM (Ser1981)
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q13315
Immunogen
Synthetic peptide corresponding to a.a. 1974-1988 of human ATM with phosphorylated Ser1981 (SLAFEEG[pS]QSTTISS).
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_000042
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
10H11.E12
Conjugate
Unconjugated
Gene
ATM, AT
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Reacts with ATM Kinase phosphorylated at serine 1981. Clone 10H11.E12 is covered by US patent No. 6,916,627 and 7,108,992.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Serine-protein kinase ATM (EC 2.7.11.1; UniProt Q13315; also known as A-T mutated, Ataxia telangiectasia mutated) is encoded by the ATM (also known as AT) gene (Gene ID 472) in human
- Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair
- Mutation in the ATM gene results in the autosomal recessive disease ataxia telangiectasia (AT)
- Known ATM substrates include p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1
- The S/TQ sequence constitutes the essential substrates phosphorylation site motif
- Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate phosphorylation, while positively charged residues surrounding the S/TQ are negative determinants
- The complex phenotypes of cells derived from patients with AT suggests that ATM has additional cellular substrates
- ATM is present as an inactive homodimer or multimer prior to activation
- DNA double-stranded breaks induced by ionizing radiation (IR) cause rapid ATM autophosphorylation at Ser1981 in human or the Ser1987 equivalent in mouse.
Compare Similar Items
Show Difference
Antigen: phospho-ATM (Ser1981)
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q13315
Immunogen: Synthetic peptide corresponding to a.a. 1974-1988 of human ATM with phosphorylated Ser1981 (SLAFEEG[pS]QSTTISS).
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_000042
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 10H11.E12
Conjugate: Unconjugated
Gene: ATM, AT
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Reacts with ATM Kinase phosphorylated at serine 1981. Clone 10H11.E12 is covered by US patent No. 6,916,627 and 7,108,992.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
phospho-ATM (Ser1981)
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q13315
Immunogen:
Synthetic peptide corresponding to a.a. 1974-1988 of human ATM with phosphorylated Ser1981 (SLAFEEG[pS]QSTTISS).
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_000042
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
10H11.E12
Conjugate:
Unconjugated
Gene:
ATM, AT
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Reacts with ATM Kinase phosphorylated at serine 1981. Clone 10H11.E12 is covered by US patent No. 6,916,627 and 7,108,992.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Src
Classification: Monoclonal
Concentration: LYOPH
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene Accession No.: P12931
Immunogen: E. coli-derived recombinant human Src Met1-Ala79 Accession # P12931
Quantity: 25 μg
Research Discipline: __
Gene ID (Entrez): 6714
Target Species: Human
Form: Purified
Applications: Western Blot, Immunohistochemistry
Clone: 327554
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein A or G purified from hybridoma culture supernatant
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Detects human Src in direct ELISAs.
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Isotype: IgG2a
Antigen:
Src
Classification:
Monoclonal
Concentration:
LYOPH
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene Accession No.:
P12931
Immunogen:
E. coli-derived recombinant human Src Met1-Ala79 Accession # P12931
Quantity:
25 μg
Research Discipline:
__
Gene ID (Entrez):
6714
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Immunohistochemistry
Clone:
327554
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein A or G purified from hybridoma culture supernatant
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Detects human Src in direct ELISAs.
Content And Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Isotype:
IgG2a
Antigen: AMPK beta 2/PRKAB2
Classification: Monoclonal
Concentration: LYOPH
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene Accession No.: O43741
Immunogen: E. coli-derived recombinant human AMPK beta 2 Met1-Ile272 Accession # O43741
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): 5565
Target Species: Human, Mouse
Form: Purified
Applications: Western Blot
Clone: 376938
Conjugate: Unconjugated
Gene: __
Host Species: Rat
Purification Method: Protein A or G purified from hybridoma culture supernatant
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Detects human and mouse AMPK beta 2 in Western blots. No cross-reactivity with recombinant human AMPK beta 1 is observed.
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Isotype: IgG2b
Antigen:
AMPK beta 2/PRKAB2
Classification:
Monoclonal
Concentration:
LYOPH
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene Accession No.:
O43741
Immunogen:
E. coli-derived recombinant human AMPK beta 2 Met1-Ile272 Accession # O43741
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
5565
Target Species:
Human, Mouse
Form:
Purified
Applications:
Western Blot
Clone:
376938
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rat
Purification Method:
Protein A or G purified from hybridoma culture supernatant
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Detects human and mouse AMPK beta 2 in Western blots. No cross-reactivity with recombinant human AMPK beta 1 is observed.
Content And Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Isotype:
IgG2b
Antigen: MafK
Classification: Monoclonal
Concentration: LYOPH
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene Accession No.: O60675
Immunogen: E. coli-derived recombinant human MafK Thr2-Ser156 Accession # O60675
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): 7975
Target Species: Human, Mouse
Form: Purified
Applications: Western Blot
Clone: 381923
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein A or G purified from hybridoma culture supernatant
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Detects human and mouse MafK in Western blots. In Western blots, no cross-reactivity with recombinant human (rh) MafB or rhMafF is observed. In Western blots, prolonged film exposures may slightly detect rhMafG.
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Isotype: IgG2b
Antigen:
MafK
Classification:
Monoclonal
Concentration:
LYOPH
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS. with No Preservative
Gene Accession No.:
O60675
Immunogen:
E. coli-derived recombinant human MafK Thr2-Ser156 Accession # O60675
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
7975
Target Species:
Human, Mouse
Form:
Purified
Applications:
Western Blot
Clone:
381923
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein A or G purified from hybridoma culture supernatant
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Detects human and mouse MafK in Western blots. In Western blots, no cross-reactivity with recombinant human (rh) MafB or rhMafF is observed. In Western blots, prolonged film exposures may slightly detect rhMafG.
Content And Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Isotype:
IgG2b