MABE175MI
MilliporeSigma™ PML Isoform II, Mouse, Unlabeled, Clone: 1A8.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE175MI-Each-of-1 | In Stock | ₹ 31,368.01 |
MABE175MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 31,368.01
GST (18%): ₹ 5,646.242
Total Price: ₹ 37,014.252
Antigen
PML Isoform II
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P29590-8
Immunogen
KLH-conjugated linear peptide corresponding to a C-terminal sequence of human PML Isoform II.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_150242
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1A8.1
Conjugate
Unconjugated
Gene
PML, MYL, PP8675, RNF71, TRIM19
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1A8.1 was raised against an C-terminal region sequence unique to PML isoform II (PML-2), but not present in the other 11 PML spliced isoforms reported by UniProt (P29590).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Protein PML (UniProt P29590; also known as Promyelocytic leukemia protein, RING finger protein 71, Tripartite motif-containing protein 19) is encoded by the PML (also known as MYL, PP8675, RNF71, TRIM19) gene (Gene ID 5371) in human
- The human PML gene/protein adopted its name when it was originally discovered as an RARα fusion protein caused by chromosomal translocation in acute promyelocytic leukemia (APL) patients
- In normal cells, the PML protein interacts with multiple protein partners in the nucleus to form PML nuclear bodies (PML-NBs) that mediate a variety of cellular functions including senescence, apoptosis, protein degradation, telemere stasbility, and antiviral defense
- At least 12 PML isoforms are generated by alternative splicings, including six nuclear isoforms (PML-I to PML-VI) and the cytoplasmic isoform PML-VII (a.k.a
- PML-VIIB), other spliced isoforms wihtout exon 6-coding sequence (a.a
- 467-552) are likewise expected to be cytoplasmic due to the abscence of nuclear localization signal (NLS) encoded by exon 6
- All isoforms share the same N-terminal region (a.a
- 1-419) containing the RBCC/tripartite motif and may have related functions due to their common functional RBCC/TRIM domain, while increasing evidences also suggest that each PML isoform possesses distinct functions mediated by its specific C-terminal sequence
- Isoform PML-1 (a.k.a
- PML-I, TRIM19alpha; UniProt P29590-1) and PML-2 (a.k.a
- PML-II or TRIM19kappa; UniProt P29590-8) share the same N-terminal 570-a.a
- sequence (encoded by exons 1 to 7a), however PML-1 derives its remaining C-terminal sequence (a.a
- 571-882) from exons 8a and 9, while PML-II derives its (a.a
- 571-829) from exon 7b with a different reading frame as that of PML-V.
Compare Similar Items
Show Difference
Antigen: PML Isoform II
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P29590-8
Immunogen: KLH-conjugated linear peptide corresponding to a C-terminal sequence of human PML Isoform II.
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_150242
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 1A8.1
Conjugate: Unconjugated
Gene: PML, MYL, PP8675, RNF71, TRIM19
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1A8.1 was raised against an C-terminal region sequence unique to PML isoform II (PML-2), but not present in the other 11 PML spliced isoforms reported by UniProt (P29590).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
PML Isoform II
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P29590-8
Immunogen:
KLH-conjugated linear peptide corresponding to a C-terminal sequence of human PML Isoform II.
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_150242
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
1A8.1
Conjugate:
Unconjugated
Gene:
PML, MYL, PP8675, RNF71, TRIM19
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1A8.1 was raised against an C-terminal region sequence unique to PML isoform II (PML-2), but not present in the other 11 PML spliced isoforms reported by UniProt (P29590).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: phospho-E2F1 (Ser375)
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to 17 amino acids surrounding phosphoserine 375 from the C-terminal region of human transcription factor E2F1.
Quantity: 100 μL
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_005216.1
Target Species: Human
Form: Purified
Applications: Western Blot, ELISA
Clone: 71-10
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 71-10 is a rabbit monoclonal antibody that specifically detects human E2F1 phosphorylated on Serine 375.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG
Antigen:
phospho-E2F1 (Ser375)
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to 17 amino acids surrounding phosphoserine 375 from the C-terminal region of human transcription factor E2F1.
Quantity:
100 μL
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_005216.1
Target Species:
Human
Form:
Purified
Applications:
Western Blot, ELISA
Clone:
71-10
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 71-10 is a rabbit monoclonal antibody that specifically detects human E2F1 phosphorylated on Serine 375.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG
Antigen: phospho-E2F1 (Ser375)
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to 17 amino acids surrounding phosphoserine 375 from the C-terminal region of human transcription factor E2F1.
Quantity: 25 μL
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_005216.1
Target Species: Human
Form: Purified
Applications: Western Blot, ELISA
Clone: 71-10
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 71-10 is a rabbit monoclonal antibody that specifically detects human E2F1 phosphorylated on Serine 375.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG
Antigen:
phospho-E2F1 (Ser375)
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to 17 amino acids surrounding phosphoserine 375 from the C-terminal region of human transcription factor E2F1.
Quantity:
25 μL
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_005216.1
Target Species:
Human
Form:
Purified
Applications:
Western Blot, ELISA
Clone:
71-10
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 71-10 is a rabbit monoclonal antibody that specifically detects human E2F1 phosphorylated on Serine 375.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG
Antigen: ADAR1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: His-tagged recombinant fragment corresponding to 401 amino acids from the internal region of murine Double-stranded RNA-specific adenosine deaminase (ADAR1). Immunogen sequnece is conserved isoforms 1 and 2.
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_062629.3
Target Species: Mouse, Human
Form: Purified
Applications: Western Blot
Clone: RD4B11
Conjugate: Unconjugated
Gene: __
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone RD4B11 is a rat monoclonal antibody that detects Double-stranded RNA-specific adenosine deaminase in human and murine cells.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
ADAR1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
His-tagged recombinant fragment corresponding to 401 amino acids from the internal region of murine Double-stranded RNA-specific adenosine deaminase (ADAR1). Immunogen sequnece is conserved isoforms 1 and 2.
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_062629.3
Target Species:
Mouse, Human
Form:
Purified
Applications:
Western Blot
Clone:
RD4B11
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone RD4B11 is a rat monoclonal antibody that detects Double-stranded RNA-specific adenosine deaminase in human and murine cells.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ