MABE425MI
MilliporeSigma™ DOT1L, Mouse, Unlabeled, Clone: 1A11.2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE425MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABE425MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
DOT1L
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q8TEK3
Immunogen
KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human DOT1L.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_115871
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1A11.2
Conjugate
Unconjugated
Gene
DOT1L, KIAA1814, KMT4
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1A11.2 detects both spliced isoforms of human DOT1L reported by UniProt (Q8TEK3).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43; UniProt Q8TEK3; also known as Disruptor of telomeric silencing-1 like, DOT1-like protein, H3-K79-HMTase, Histone H3-K79 methyltransferase, Lysine N-methyltransferase 4) is encoded by the DOT1L (also known as KIAA1814, KMT4) gene (Gene ID 84444) in human
- Disruptor of telomeric silencing-1 like (DOT1L) catalyzes the mono-, di-, and tri-methylation of histone H3 on lysine-79 (H3K79)
- DOT1L-mediated H3K79 methylation is associated with active transcription
- Accumulating evidences indicate a role of DOT1L and H3K79 in many biological processes, including DNA damage response, cell cycle, embryonic cell development, as well as the initiation and maintenance of mixed lineage leukemia (MLL)-rearranged leukemia
- MLL fusion proteins such as AF9, AF10, and ENL recruit DOT1L to their target gene loci to help promote the transcription of genes that contribute to leukemic transformation of hematopoietic progenitor cells
- DOT1L also has been identified as a coactivator of Wnt signaling in colorectal cancer, and is shown to induce neoplastic transformation of immortalized human breast epithelial cells and increase tumor initiation and growth of human breast cancer cells
- In addtion, DOT1L is reported to regulate androgen receptor activity via direct methylation.
Compare Similar Items
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Antigen: DOT1L
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q8TEK3
Immunogen: KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human DOT1L.
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_115871
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 1A11.2
Conjugate: Unconjugated
Gene: DOT1L, KIAA1814, KMT4
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1A11.2 detects both spliced isoforms of human DOT1L reported by UniProt (Q8TEK3).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
DOT1L
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q8TEK3
Immunogen:
KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human DOT1L.
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_115871
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
1A11.2
Conjugate:
Unconjugated
Gene:
DOT1L, KIAA1814, KMT4
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1A11.2 detects both spliced isoforms of human DOT1L reported by UniProt (Q8TEK3).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: WDR5
Classification: Monoclonal
Concentration: __
Formulation: Mouse monoclonal IgG2b ascitic fluid containing up to 0.1% sodium azide.
Gene Accession No.: __
Immunogen: Purified recombinant fragment of human WDR5 expressed in E. Coli.
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Ascites
Applications: Western Blot
Clone: 7B11
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: −20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype: IgG2b
Antigen:
WDR5
Classification:
Monoclonal
Concentration:
__
Formulation:
Mouse monoclonal IgG2b ascitic fluid containing up to 0.1% sodium azide.
Gene Accession No.:
__
Immunogen:
Purified recombinant fragment of human WDR5 expressed in E. Coli.
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Ascites
Applications:
Western Blot
Clone:
7B11
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
−20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype:
IgG2b
Antigen: TIP60
Classification: Monoclonal
Concentration: __
Formulation: Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Gene Accession No.: __
Immunogen: Purified recombinant fragment of human TIP60 expressed in E. Coli.
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Ascites
Applications: Immunohistochemistry, Western Blot
Clone: 3F9
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: −20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype: IgG2b
Antigen:
TIP60
Classification:
Monoclonal
Concentration:
__
Formulation:
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Gene Accession No.:
__
Immunogen:
Purified recombinant fragment of human TIP60 expressed in E. Coli.
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Ascites
Applications:
Immunohistochemistry, Western Blot
Clone:
3F9
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
−20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype:
IgG2b
Antigen: PRMT1
Classification: Monoclonal
Concentration: __
Formulation: Purified rat monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: NP_001527
Immunogen: BSA-conjugated linear peptide corresponding to human PRMT1.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human, Mouse, Rat
Form: Purified
Applications: Western Blot
Clone: 7D2
Conjugate: Unconjugated
Gene: __
Host Species: Rat
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG2a κ
Antigen:
PRMT1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified rat monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
NP_001527
Immunogen:
BSA-conjugated linear peptide corresponding to human PRMT1.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human, Mouse, Rat
Form:
Purified
Applications:
Western Blot
Clone:
7D2
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rat
Purification Method:
Protein G purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG2a κ