MABE990MI
MilliporeSigma™ MSL-2, Mouse, Unlabeled, Clone: 10C3.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE990MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABE990MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
MSL-2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9HCI7
Immunogen
GST-tagged recombinant human MSL-2 C-terminal fragment.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_060603
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
10C3.1
Conjugate
Unconjugated
Gene
MSL2, KIAA1585, MSL2L1, RNF184
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both spliced isoforms of human MSL2 reported by UniProt (Q9HCI7).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- E3 ubiquitin-protein ligase MSL2 (UniProt Q9HCI7; also known as Male-specific lethal-2 homolog, Male-specific lethal-2 homolog 1, Male-specific lethal 2-like 1, MSL-2, MSL2-like 1, RING finger protein 184) is encoded by the MSL2 (also known as KIAA1585, MSL2L1, RNF184) gene (Gene ID 55167) in human
- MSL2 (male-specific lethal 2) was originally identified in Drosophila and characterized as a gene whose mution causes male-specific lethality
- Human MSL (hMSL) orthologues are found in an evolutionary conserved complex known as the hMOF (Males absent on the first, human) complex that is composed of hMOF, hMSL1, hMSL2, hMSL3, and Nucleoprotein 153 (NUP153)
- MSL2 is a RING domain-containing E3 ligase that targets the tumor suppressor p53 Lys351 for monoubiquitination, exposing a nuclear export motif within p53 as well as releasing p53 from MDM2
- MSL2 overexpression causes an upregulation of mitochondrial-dependent apoptosis as a result of p53 cytoplasmic accumulation
- hMSL1/hMSL2 heterodimer is reported to ubiquitinate histone H2B on Lys34 (H2BK34ub), which promotes transcription activation by stimulating the activities of MLL/SET1 family H3K4 methyltransferases and the H3K79 methyltransferase DOT1L
- In addition, both hMSL1 and hMOF are reported to be modified by hMSL2 following DNA damage induction, and hMSL2-depletion causes impaired non-homologous end joining (NHEJ) repair in human cells.
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Antigen: MSL-2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q9HCI7
Immunogen: GST-tagged recombinant human MSL-2 C-terminal fragment.
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_060603
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 10C3.1
Conjugate: Unconjugated
Gene: MSL2, KIAA1585, MSL2L1, RNF184
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with both spliced isoforms of human MSL2 reported by UniProt (Q9HCI7).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
MSL-2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q9HCI7
Immunogen:
GST-tagged recombinant human MSL-2 C-terminal fragment.
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_060603
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
10C3.1
Conjugate:
Unconjugated
Gene:
MSL2, KIAA1585, MSL2L1, RNF184
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with both spliced isoforms of human MSL2 reported by UniProt (Q9HCI7).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Antigen: NKG2D (CD314)
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: Whole NKL cells (aggressive cell line derived from human natural killer cell leukemia).
Quantity: 25 μL
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone: 1D11
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1D11 detects NKG2-D type II integral membrane protein in human cells.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Antigen:
NKG2D (CD314)
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
Whole NKL cells (aggressive cell line derived from human natural killer cell leukemia).
Quantity:
25 μL
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone:
1D11
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1D11 detects NKG2-D type II integral membrane protein in human cells.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Antigen: CCRL2 (Mouse)
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to the N-terminal end sequence of mouse CCRL2 (Zabel, B.A., et al. (2008). J. Exp. Med. 205(10):2207-2220).
Quantity: 100 μg
Research Discipline: Inflammation and Immunology
Gene ID (Entrez): NP_001289305.1
Target Species: Mouse
Form: Purified
Applications: Flow Cytometry
Clone: BZ2E3
Conjugate: Unconjugated
Gene: __
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone BZ2E3 reacts with mCCRL2, but not mCMKLR1, huCMKLR1, mCRTH2, huCCRL2, or mCCR10. Clone BZ2E3 immunostained the surface of mCCRL2-expressing cells, but not non-mCCRL2-expressing cells (Monnier, J., et al. (2012). J. Immunol. 189(2):956-967; Zabel, B.A., et al. (2008). J. Exp. Med. 205(10):2207-2220).
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
CCRL2 (Mouse)
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to the N-terminal end sequence of mouse CCRL2 (Zabel, B.A., et al. (2008). J. Exp. Med. 205(10):2207-2220).
Quantity:
100 μg
Research Discipline:
Inflammation and Immunology
Gene ID (Entrez):
NP_001289305.1
Target Species:
Mouse
Form:
Purified
Applications:
Flow Cytometry
Clone:
BZ2E3
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone BZ2E3 reacts with mCCRL2, but not mCMKLR1, huCMKLR1, mCRTH2, huCCRL2, or mCCR10. Clone BZ2E3 immunostained the surface of mCCRL2-expressing cells, but not non-mCCRL2-expressing cells (Monnier, J., et al. (2012). J. Immunol. 189(2):956-967; Zabel, B.A., et al. (2008). J. Exp. Med. 205(10):2207-2220).
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ