MABE949MI

MilliporeSigma™ E3 Ubiquitin Ligase BRE1B, Mouse, Unlabeled, Clone: 4H8.1,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABE949MI-Each-of-1 In Stock ₹ 40,197.80

MABE949MI - Each of 1

₹ 40,197.80

In Stock

Quantity

1

Base Price: ₹ 40,197.80

GST (18%): ₹ 7,235.604

Total Price: ₹ 47,433.404

Antigen

E3 Ubiquitin Ligase BRE1B

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.

O75150

Immunogen

GST-tagged recombinant internal fragment from the C-terminal half of human BRE1B .

Quantity

100 μL

Research Discipline

Epigenetics & Nuclear Function

Gene ID (Entrez)

NP_001193962

Target Species

Human

Form

Purified

Applications

Western Blot

Clone

4H8.1

Conjugate

Unconjugated

Gene

RNF40, BRE1B, KIAA0661

Host Species

Mouse

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Clone 4H8.1 epitope region is present in all three spliced isoforms of human BRE1B reported by UniProt (O75150).

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Isotype

IgG1 κ

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Description

  • E3 ubiquitin-protein ligase BRE1B (UniProt O75150; also known as 95kDa retinoblastoma-associated protein, BRE1-B, RBP95, RING finger protein 40, Syntaxin-1-interacting RING finger protein, Protein staring) is encoded by the RNF40 (also known as BRE1B, KIAA0661) gene (Gene ID 9810) in human
  • Proteini ubiquitination is mediated by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s)
  • There exist RING finger-type (really interesting new gene), HECT-type (homologous to E6-AP C-terminus), and U-box type of E3 ligases
  • RING finger ubiquitin ligase members can function as monomers, dimers, or multi-subunit complexes
  • The RNF20-RNF40 heterodimer mediates the ubiquitination of histone H2B at Lysine 120, an event that plays an important role in decompacting chromatin fiber to allow transcription elongation, in stem cell differentiation, as well as in DNA double-strand breaks (DSBs) repair via the homologous recombination (HR) and nonhomologous end-joining (NHEJ) pathways
  • Human RNF40 is a 1001-amino acid protein containing a RING-type zinc finger in its C-terminal region (a.a
  • 948-987) that mediates its interaction with RNF20.

Compare Similar Items

Show Difference

Img

MilliporeSigma™

MABE949MI

--


Antigen:
E3 Ubiquitin Ligase BRE1B

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
O75150

Immunogen:
GST-tagged recombinant internal fragment from the C-terminal half of human BRE1B .

Quantity:
100 μL

Research Discipline:
Epigenetics & Nuclear Function

Gene ID (Entrez):
NP_001193962

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
4H8.1

Conjugate:
Unconjugated

Gene:
RNF40, BRE1B, KIAA0661

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone 4H8.1 epitope region is present in all three spliced isoforms of human BRE1B reported by UniProt (O75150).

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG1 κ

Img

MilliporeSigma

MABE951MI

--


Antigen:
Histone H3.3

Classification:
Monoclonal

Concentration:
1mg/mL

Formulation:
Purified rat monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
NP_002098

Immunogen:
KLH-conjugated linear peptide corresponding to human Histone H3.3.

Quantity:
100 μg

Research Discipline:
__

Gene ID (Entrez):
__

Target Species:
Canine, Human, Monkey, Mouse

Form:
Purified

Applications:
Western Blot

Clone:
6C4A3

Conjugate:
Unconjugated

Gene:
__

Host Species:
Rat

Purification Method:
Protein G purified

Regulatory Status:
__

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
2-8°C for one year

Isotype:
IgG2a κ

Img

MilliporeSigma

MABE952MI

--


Antigen:
Histone H3.1

Classification:
Monoclonal

Concentration:
1mg/mL

Formulation:
Purified rat monoclonal in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
NP_003520

Immunogen:
KLH-conjugated linear peptide corresponding to human Histone H3.1.

Quantity:
100 μg

Research Discipline:
__

Gene ID (Entrez):
__

Target Species:
Human, Mouse

Form:
Purified

Applications:
ChIP Assay, Immunocytochemistry, Immunoprecipitation, Western Blot

Clone:
1D4F2

Conjugate:
Unconjugated

Gene:
__

Host Species:
Rat

Purification Method:
Protein G purified

Regulatory Status:
__

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
2-8°C for one year

Isotype:
__

Img

MilliporeSigma

MABE953MI

--


Antigen:
phospho RNA Pol II (Ser2)

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified rat monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
NP_000928

Immunogen:
KLH-conjugated linear peptide corresponding to human RNA Pol II phosphorylated at Ser2.

Quantity:
100 μg

Research Discipline:
__

Gene ID (Entrez):
__

Target Species:
Canine, Human, Monkey, Mouse, Rat

Form:
Purified

Applications:
ChIP Assay, ELISA, Immunocytochemistry, Western Blot

Clone:
3E7C7

Conjugate:
Unconjugated

Gene:
__

Host Species:
Rat

Purification Method:
Protein G purified

Regulatory Status:
__

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
2-8°C for one year

Isotype:
IgG2a κ