MilliporeSigma™ LMO-2 (Rhombotin-2), Mouse, Unlabeled, Clone: 1A9-3B11,

Description

• Rhombotin-2 (UniProt P25791; also known as Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, T-cell translocation protein 2) is encoded by the LMO2 (also known as RBTN2, RBTNL1, RHOM2, TTG2) gene (Gene ID 4005) in human
• Rhombotin-2 is 158 amino acids, small cysteine-rich protein with multiple functions
• A large portion of its structure is occupied by tandemly repeated cysteine-rich zinc-finger binding motifs, the LIM domains
• However, it does not have any identifiable DNA-binding motifs
• It is found predominantly in the nucleus or in the cytoplasm depending upon both the tissue and the cell type
• For example, in kidney it is predominantly localized in the cytoplasm, but in hematopoietic cells it has nuclear localization
• LMO2 is reported to be a proto-oncogene only in the context of T lymphocytes and plays a role in T-cell leukemogenesis
• It also has distinct functions in erythropoiesis
• It acts with TAL1/SCL to regulate red blood cell development and interacts with LDB1 to maintain erythroid precursors in an immature state
• It is reported to interact with retinoblastoma-binding protein 2 (RBP2) and human Bex2 (brain expressed X-linked), both of which are shown to enhance its transcriptional activity
• A chromosomal aberration involving LMO2 has been linked to T-cell acute lymphoblastic leukemia (T-ALL)
• Ref.: Mao S., et al
• (1997) Oncogene 14, 1531-1539.