MABC576MI
MilliporeSigma™ Mouse anti-HOIL-1, Clone: 2E2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC576MI-Each-of-1 | In Stock | ₹ 41,643.76 |
MABC576MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,643.76
GST (18%): ₹ 7,495.877
Total Price: ₹ 49,139.637
Antigen
HOIL-1
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
RBCK1; C20orf18; RNF54; UBCE7IP3; XAP3; XAP4
Immunogen
GST-tagged recombinant protein corresponding to human HOIL-1 near the C-terminus.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_006453
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunocytochemistry, Western Blot
Clone
2E2
Gene Accession No.
Q9BYM8
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
Related Products
Description
- Specifically detects HOIL-1 clone: 2E2 in Human, Mouse samples, and it is validated for Immunocytochemistry, Western Blotting RanBP-type and C3HC4-type zinc finger-containing protein 1 (UniProt Q9BYM8; also known as HOIL-1, HBV-associated factor 4, Heme-oxidized IRP2 ubiquitin ligase 1, Hepatitis B virus X-associated protein 4, RBCC protein interacting with PKC1, RING finger protein 54, Ubiquitin-conjugating enzyme 7-interacting protein 3) is encoded by the RBCK1 gene (also known as C20orf18, HOIL1, PBMEI, RBCK2, RNF54, UBCE7IP3, XAP3, XAP4, ZRANB4) (Gene ID 10616) in human
- The linear ubiquitin assembly complex (LUBAC) is comprised of two RING-IBR-RING (RBR)-containing E3 ligases, HOIL-1L and HOIP
- LUBAC conjugates a head-to-tail-linked linear polyubiquitin chain onto lysine residues on substrate proteins
- Ovarian tumor deubiquitinating enzyme (DUB) with linear linkage specificity (OTULIN/Gumby/FAM105B) and cylindromatosis (CYLD) are two DUBs that catalyze the cleavage linear polyubiquitin chains
- OTULIN and CYLD interact with the N-terminal PNGase/UBA or UBX (PUB) domain of HOIP and negatively regulate LUBAC-mediated cellular processes
- LUBAC is reported to suppress IFN-dependent antiviral activity by mediating TRIM25 degradation and competing against TRIM25 for RIG-I interaction.
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Antigen: HOIL-1
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: RBCK1; C20orf18; RNF54; UBCE7IP3; XAP3; XAP4
Immunogen: GST-tagged recombinant protein corresponding to human HOIL-1 near the C-terminus.
Quantity: 100 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_006453
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Western Blot
Clone: 2E2
Gene Accession No.: Q9BYM8
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
HOIL-1
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
RBCK1; C20orf18; RNF54; UBCE7IP3; XAP3; XAP4
Immunogen:
GST-tagged recombinant protein corresponding to human HOIL-1 near the C-terminus.
Quantity:
100 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_006453
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Western Blot
Clone:
2E2
Gene Accession No.:
Q9BYM8
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Antigen: __
Classification: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Isotype:
__
Applications:
__
Clone:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: hIAP-1/BIRC3
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: BIRC3; API2; IAP1; MIHC; RNF49
Immunogen: GST-tagged recombinant protein corresponding to the BIR 1/2 of human hIAP-1/BIRC3.
Quantity: 100 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_001156
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot
Clone: 11D12.1
Gene Accession No.: Q13489
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
hIAP-1/BIRC3
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
BIRC3; API2; IAP1; MIHC; RNF49
Immunogen:
GST-tagged recombinant protein corresponding to the BIR 1/2 of human hIAP-1/BIRC3.
Quantity:
100 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_001156
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
11D12.1
Gene Accession No.:
Q13489
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: Sulf-2
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: SULF2, KIAA1247
Immunogen: Recombinant protein corresponding to Human Sulf-2.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: 2-8°C for one year
Isotype: IgG1 κ
Applications: ELISA, Immunohistochemistry, Western Blot
Clone: 2B4
Gene Accession No.: NP_001155313
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Sulf-2
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
SULF2, KIAA1247
Immunogen:
Recombinant protein corresponding to Human Sulf-2.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
2-8°C for one year
Isotype:
IgG1 κ
Applications:
ELISA, Immunohistochemistry, Western Blot
Clone:
2B4
Gene Accession No.:
NP_001155313
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified