MABE1025MI
MilliporeSigma™ Tankyrase-2, Mouse, Unlabeled, Clone: 2F5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1025MI-Each-of-1 | In Stock | ₹ 36,249.21 |
MABE1025MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,249.21
GST (18%): ₹ 6,524.858
Total Price: ₹ 42,774.068
Antigen
Tankyrase-2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9H2K2
Immunogen
GST-tagged recombinant human Tankyrase-2 fragment from the region between ANK repeats 6 & 8.
Quantity
100 μg
Research Discipline
Epigenetics & Nuclear Function
Gene ID (Entrez)
NP_079511
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
2F5.1
Conjugate
Unconjugated
Gene
TNKS2, PARP5B, TANK2, TNKL
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 2F5.1 recognizes an epitope in the region between ANK repeats 6 & 8 of human Tanyrase-2.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- Tankyrase-2 (EC 2.4.2.30; UniProt Q9H2K2; also known as ADP-ribosyltransferase diphtheria toxin-like 6, ARTD6, PARP-5B, Poly [ADP-ribose] polymerase 5B, TANK2, TNKS-2, Tankyrase II, Tankyrase-like protein, Tankyrase-related protein, TRF1-interacting ankyrin-related ADP-ribose polymerase 2) is encoded by the TNKS2 (also known as PARP5B, TANK2, TNKL) gene (Gene ID 80351) in human
- Tankyrase-2 belongs to the poly(ADP-ribosylation) polymerase (PARP) family of enzymes that mediate post-translational modification of proteins by poly(ADP-ribosyl)ation, where repeating units of ADP-ribose linked by glycosidic bonds were added to aspartate, glutamate, asparagine, arginine or lysine residues of substrate proteins
- Poly(ADP-ribose) (PAR) modification is reversible through the action of poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl protein lyase
- Tankyrase-2 and the related Tankyrase-1 share a common domain organization with 15 N-terminal ankyrin-repeats (a.a
- 57-776 in TNKS2) involved in substrate recognition, a sterile alpha motif (SAM) domain (a.a
- 873-936 in TNKS2) required for dimerization, followed by the C-terminal PARP domain (a.a
- 959-1164 in TNKS2)
- Mice with either Tnks1- or Tnks2-knockout are viable, while double Tnks1-/Tnks2-knockout is lethal at embryonic day 9.5, suggesting a functional redundancy between these two enzymes
- Both tankyrases target and suppress Axin2, a well known β-catenin negative regulator
- Tankyrase-2 ribosylates Src-binding adapter protein 3BP2, leading to its ubiquitination and proteasomal degradation in macrophages and osteoclasts
- Loss of tankyrase-mediated 3BP2 negative regulation underlies the pathogenic mechanism of cherubism, an autosomal dominant disorder affecting cranial bone development.
Compare Similar Items
Show Difference
Antigen: Tankyrase-2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q9H2K2
Immunogen: GST-tagged recombinant human Tankyrase-2 fragment from the region between ANK repeats 6 & 8.
Quantity: 100 μg
Research Discipline: Epigenetics & Nuclear Function
Gene ID (Entrez): NP_079511
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 2F5.1
Conjugate: Unconjugated
Gene: TNKS2, PARP5B, TANK2, TNKL
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 2F5.1 recognizes an epitope in the region between ANK repeats 6 & 8 of human Tanyrase-2.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
Tankyrase-2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q9H2K2
Immunogen:
GST-tagged recombinant human Tankyrase-2 fragment from the region between ANK repeats 6 & 8.
Quantity:
100 μg
Research Discipline:
Epigenetics & Nuclear Function
Gene ID (Entrez):
NP_079511
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
2F5.1
Conjugate:
Unconjugated
Gene:
TNKS2, PARP5B, TANK2, TNKL
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 2F5.1 recognizes an epitope in the region between ANK repeats 6 & 8 of human Tanyrase-2.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: poly-ADP-ribose binding reagent
Classification: Polyclonal
Concentration: __
Formulation: Purified fromE. coliby Ni-NTA agarose. Supplied in buffer containing 10mM Tris pH 7.5, 0.2M NaCl, 10% Glycerol, 10mM Imidazole, 1mM PMSF, 1mM β-Mercaptoethanol, 10% glycerol without preservatives.
Gene Accession No.: __
Immunogen: __
Quantity: 200 μL
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: Human, Mouse
Form: Purified
Applications: Dot Blot
Clone: __
Conjugate: __
Gene: __
Host Species: E. coli
Purification Method: Ni-NTA agarose
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -80°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype: __
Antigen:
poly-ADP-ribose binding reagent
Classification:
Polyclonal
Concentration:
__
Formulation:
Purified fromE. coliby Ni-NTA agarose. Supplied in buffer containing 10mM Tris pH 7.5, 0.2M NaCl, 10% Glycerol, 10mM Imidazole, 1mM PMSF, 1mM β-Mercaptoethanol, 10% glycerol without preservatives.
Gene Accession No.:
__
Immunogen:
__
Quantity:
200 μL
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
Human, Mouse
Form:
Purified
Applications:
Dot Blot
Clone:
__
Conjugate:
__
Gene:
__
Host Species:
E. coli
Purification Method:
Ni-NTA agarose
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -80°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype:
__
Antigen: SMARCB1
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q12824
Immunogen: GST-tagged recombinant protein corresponding to human SMARCB1.
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_001007469
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Western Blot
Clone: 2C2
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
SMARCB1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q12824
Immunogen:
GST-tagged recombinant protein corresponding to human SMARCB1.
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_001007469
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Western Blot
Clone:
2C2
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Nup96
Classification: Monoclonal
Concentration: __
Formulation: Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q6PFD9
Immunogen: GST-tagged recombinant protein corresponding to mouse Nup96 near the N-terminus.
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_001274093
Target Species: Mouse
Form: Purified
Applications: Immunocytochemistry, Western Blot
Clone: 4H5
Conjugate: __
Gene: __
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Nup96
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q6PFD9
Immunogen:
GST-tagged recombinant protein corresponding to mouse Nup96 near the N-terminus.
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_001274093
Target Species:
Mouse
Form:
Purified
Applications:
Immunocytochemistry, Western Blot
Clone:
4H5
Conjugate:
__
Gene:
__
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ