MilliporeSigma™ Syndecan-1, Mouse, Unlabeled, Clone: 11G2.1,

Description

• Syndecan-1 (UniProt P18827; also known as CD138, SYND1) is encoded by the SDC1 (also known as SDC) gene (Gene ID 6382) in human
• Syndecan-1 belongs to a family of transmembrane heparan sulfate proteoglycans (HSPGs), members of which also include syndecan-2 (fibroglycan, SDC2), syndecan-3 (N-syndecan, SDC3), and syndecan-4 (amphiglycan, ryudocan, SDC4)
• Syndecan-1 is produced with a signal peptide (a.a
• 1-22), the removal of which yields the mature protein with a large extracellular region (a.a
• 23-254), a transmembrane segment (a.a
• 255-275), and a cytoplasmic tail (a.a
• 276-310)
• Syndecan-1 is modified at its extracellular domain on a.a
• 45 and 47 with O-linked heparan sulfate (HS) that plays an important role in mediating its interaction with HS-binding protein, including growth factors (e.g
• bFGF/FGF2, PDGF, TGF-β, and VEGF) and extracellular matrix proteins (e.g
• collagens, fibronectin, thrombospondin, and tenascin)
• Syndecan-1 thus funtions as a coreceptor for growth factor receptors and acts as an anchor connecting the extracellular matrix to the intracellular cytoskeleton
• Syndecan extracellular domain can be proteolytically cleaved off at a juxtamembrane site and upregulated shedding of the ectodomain occurs in response to growth factors, chemokines, heparanase, microbial toxins, insulin, and cellular stress
• SDC1 deregulation contributes to cancer progression by promoting angiogenesis and cancer cell proliferation, metastasis, and invasion.