MABT528MI
MilliporeSigma™ Connexin 43, CT, Mouse, Unlabeled, Clone: 1C5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT528MI-Each-of-1 | In Stock | ₹ 48,852.19 |
MABT528MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,852.19
GST (18%): ₹ 8,793.394
Total Price: ₹ 57,645.584
Antigen
Connexin 43, CT
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P17302
Immunogen
GST-tagged recombinant human connexin 43 C-terminal cytoplasmic tail fragment.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_000156
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
1C5.1
Conjugate
Unconjugated
Gene
GJA1, AVSD3, CMDR, GJAL, HSS, ODDD
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1C5.1 targets an epitope within the second half of the C-terminal cytoplasmic tail.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Gap junction alpha-1 protein (UniProt P17302; also known as Connexin-43, Cx43, Gap junction 43kDa heart protein) is encoded by the GJA1 (also known as AVSD3, CMDR, GJAL, HSS, ODDD) gene (Gene ID 2697) in human
- A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexins, through which materials of low molecular weight diffuse from one cell to a neighboring cell
- Connexin-43 is a polytopic integral membrane protein oligomerizes into a hexamer or connexon
- It is he most ubiquitously expressed connexin and contains a long C-terminal tail, an N-terminal domain, and multiple transmembrane domains
- The C-terminal tail domain of human connexin-43 contains 50 amino acids and includes post-translational modification sites, as well as binding sites for transcription factors, cytoskeleton elements, and other proteins
- The C-terminal tail regulates pH gating and channel assembly, whereas the N-terminal domain is involved in channel gating and oligomerization and controls the switch between channel open and closed states
- Mutations in connexin-43 result in multiple disorders, such as oculodentodigital dysplasia that is characterized by microcornea, microphthalmia, and syndactyly of the fourth and fifth fingers
- Connexin-43 is shown to negatively regulate growth of colon cancer cells, in part by enhancing apoptosis
- Loss of connexin-43 expression in colorectal cancers is correlated with significantly shorter relapse-free and overall survival.
Compare Similar Items
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Antigen: Connexin 43, CT
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P17302
Immunogen: GST-tagged recombinant human connexin 43 C-terminal cytoplasmic tail fragment.
Quantity: 100 μg
Research Discipline: Cell Structure
Gene ID (Entrez): NP_000156
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 1C5.1
Conjugate: Unconjugated
Gene: GJA1, AVSD3, CMDR, GJAL, HSS, ODDD
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1C5.1 targets an epitope within the second half of the C-terminal cytoplasmic tail.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Connexin 43, CT
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P17302
Immunogen:
GST-tagged recombinant human connexin 43 C-terminal cytoplasmic tail fragment.
Quantity:
100 μg
Research Discipline:
Cell Structure
Gene ID (Entrez):
NP_000156
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
1C5.1
Conjugate:
Unconjugated
Gene:
GJA1, AVSD3, CMDR, GJAL, HSS, ODDD
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1C5.1 targets an epitope within the second half of the C-terminal cytoplasmic tail.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: N-cadherin
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: GST/His-tagged recombinant fragment corresponding to 79 amino acids from the N-terminal half of human cadherin-2.
Quantity: 100 μL
Research Discipline: Cell Structure
Gene ID (Entrez): NP_001783
Target Species: Human, Rat
Form: __
Applications: Immunocytochemistry
Clone: 6A9.2
Conjugate: Alexa Fluor 488
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 6A9.2 specifically detects N-cadherin extracellular cadherin 1 domain. It targets an epitope with in a sequence of 79 amino acids in the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
N-cadherin
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
GST/His-tagged recombinant fragment corresponding to 79 amino acids from the N-terminal half of human cadherin-2.
Quantity:
100 μL
Research Discipline:
Cell Structure
Gene ID (Entrez):
NP_001783
Target Species:
Human, Rat
Form:
__
Applications:
Immunocytochemistry
Clone:
6A9.2
Conjugate:
Alexa Fluor 488
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 6A9.2 specifically detects N-cadherin extracellular cadherin 1 domain. It targets an epitope with in a sequence of 79 amino acids in the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: MMP-9
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: GST/His-tagged recombinant fragment corresponding to 110 amino acids from the C-terminal of human MMP-9.
Quantity: 100 μg
Research Discipline: Cell Structure
Gene ID (Entrez): NP_004985
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 3D6.3
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3D6.3 detects MMP-9 in human spleen. This clone targets a sequence with in 110 amino acids from the C-terminal end.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
MMP-9
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
GST/His-tagged recombinant fragment corresponding to 110 amino acids from the C-terminal of human MMP-9.
Quantity:
100 μg
Research Discipline:
Cell Structure
Gene ID (Entrez):
NP_004985
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
3D6.3
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 3D6.3 detects MMP-9 in human spleen. This clone targets a sequence with in 110 amino acids from the C-terminal end.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: PECAM-1
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P16284
Immunogen: GST-tagged recombinant human PECAM-1 cytoplasmic domain.
Quantity: 100 μg
Research Discipline: Cell Structure
Gene ID (Entrez): NP_000433
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 4A8.1
Conjugate: Unconjugated
Gene: PECAM1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 4A8.1 was raised against the cytoplasmic domain of PECAM-1 (CD31) isoform Long. Reactivity toward spliced isoforms Delta12, Delta13, Delta14, Delta14-15, and Delta15 with various cytomplasmic domain deletions is possible, but has not not been confirmed.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
PECAM-1
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P16284
Immunogen:
GST-tagged recombinant human PECAM-1 cytoplasmic domain.
Quantity:
100 μg
Research Discipline:
Cell Structure
Gene ID (Entrez):
NP_000433
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
4A8.1
Conjugate:
Unconjugated
Gene:
PECAM1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 4A8.1 was raised against the cytoplasmic domain of PECAM-1 (CD31) isoform Long. Reactivity toward spliced isoforms Delta12, Delta13, Delta14, Delta14-15, and Delta15 with various cytomplasmic domain deletions is possible, but has not not been confirmed.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ